Iron complex-catalyzed N-arylation of pyrazoles under aqueous medium

被引：43
|
作者：
Lee, Hang Wai [1 ]
Chan, Albert S. C. [1 ]
Kwong, Fuk Yee [1 ]
机构：
[1] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Open Lab Chirotechnol, Inst Mol Technol Drug Discovery & Synth, Hong Kong, Hong Kong, Peoples R China
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 42期
关键词：
CROSS-COUPLING REACTION; SULFIDE OXIDATION; HYDROGEN-PEROXIDE; BOND FORMATION; ARYL HALIDES; PALLADIUM; COPPER; LIGANDS; ULLMANN; AMINES;
D O I：
10.1016/j.tetlet.2009.08.018
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Commercially available FeCl3 center dot 6H(2)O with conformationally rigid diamine ligand is a highly effective catalyst for N-arylation of pyrazoles using aryl and heteroaryl iodides. It is notable to show that this complex is tolerable under aqueous medium and particularly the whole reaction utilizes water as the sole solvent without any additional organic co-solvents and surfactants. Attempted study using other nitrogen nucleophiles is described. This newly developed system provides an alternative protocol to Cu- and Pd-catalyzed N-arylation reactions. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5868 / 5871
页数：4
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