Strain-specific ameliorating effect of Bifidobacterium longum on atopic dermatitis in mice

被引：14
|
作者：
Fang, Zhifeng [1 ,2 ]
Li, Lingzhi [1 ,2 ]
Liu, Xinyang [1 ,2 ]
Lu, Wenwei [1 ,2 ,3 ,6 ]
Zhao, Jianxian [1 ,2 ,6 ]
Zhang, Hao [1 ,2 ,3 ,4 ,5 ,6 ]
Chen, Wei [1 ,2 ,3 ,7 ]
机构：
[1] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China
[2] Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China
[3] Jiangnan Univ, Natl Engn Res Ctr Funct Food, Wuxi 214122, Jiangsu, Peoples R China
[4] Wuxi Translat Med Res Ctr, Wuxi 214122, Jiangsu, Peoples R China
[5] Jiangsu Translat Med Res Inst, Wuxi Branch, Wuxi 214122, Jiangsu, Peoples R China
[6] Jiangnan Univ, Yangzhou Inst Food Biotechnol, Yangzhou 225004, Jiangsu, Peoples R China
[7] BTBU, Beijing Innovat Ctr Food Nutr & Human Hlth, Beijing 100048, Peoples R China
来源：
JOURNAL OF FUNCTIONAL FOODS | 2019年 / 60卷
基金：
中国国家自然科学基金;
关键词：
Bifidobacterium longum; Strain-specific; Atopic dermatitis; Immune response; Gut microbiota; DOUBLE-BLIND; ALLERGIC DISEASE; GUT MICROBIOTA; HIGH-RISK; PROBIOTICS; CHILDREN; CELL; MICROFLORA; PREVENTION; GUIDELINES;
D O I：
10.1016/j.jff.2019.103426
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Atopic dermatitis (AD) is among the most common allergic diseases worldwide. This study evaluated differences in the abilities of Bifidobacterium longum strains to alleviate 2, 4-dinitrofluorobenzene-induced AD in mice. Of the 12 tested B. longum strains, CCFM1029 significantly relieved AD symptoms. This outcome was accompanied by the inhibition of inflammatory cells infiltration in AD-like skin lesions, decreases in serum IgE, and inflammatory cytokines levels in dorsal skin tissue, increases in IFN-gamma and IL-10 levels, and a reduction in the cecal propionic acid level. B. longum CCFM1029 also reduced the proportions of unclassified Bacteroidales S24-7, Adlercreutzia, and Allobaculum spp., and restored the gut microbiota structure such that it resembled the control group structure. In conclusion, the administration of B. longum CCFM1029 helped to ameliorate AD by suppressing polarized Th2 immune responses and regulating the gut microbiota and short-chain fatty acids metabolism.
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收藏
页数：9
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