Antibacterial Performance of Terpenoids from the Australian Plant Eremophila lucida

被引：12

作者：

Biva, Israt J. ^{[1
,2
]}

Ndi, Chi P. ^{[3
]}

Semple, Susan J. ^{[3
]}

Griesser, Hans J. ^{[1
,2
]}

机构：

[1] Univ South Australia, Future Ind Inst, Mawson Lakes 5095, Australia

[2] Wound Management Innovat Cooperat Res Ctr, Toowong 4066, Australia

[3] Univ South Australia, Qual Use Med & Pharm Res Ctr, Sch Pharm & Med Sci, Frome Rd, Adelaide, SA 5000, Australia

来源：

ANTIBIOTICS-BASEL | 2019年 / 8卷 / 02期

关键词：

Eremophila; Scrophulariaceae; diterpenoid; sesquiterpenoid; antimicrobial; antibacterial; ANTIMICROBIAL COMPOUNDS; DITERPENES; CHEMISTRY; PHYTOCHEMISTRY; CONSTITUENTS;

D O I：

10.3390/antibiotics8020063

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Plants in the Australian genus Eremophila (Scrophulariaceae) have attracted considerable recent attention for their antimicrobial compounds, which possess a wide range of chemical structures. As they are typically associated with the oily-waxy resin layer covering leaves and green branchlets, and Eremophila lucida is prominent among the species containing a pronounced sticky resin layer, this species was considered of interest for assessing its antibacterial constituents. The n-hexane fraction of the crude acetone extract of the leaves exhibited antibacterial activity against Staphylococcus aureus. Isolation led to the known compounds cembratriene, (3Z, 7E, 11Z)-15-hydroxycembra-3,7,11-trien-19-oic acid (1), the sesquiterpenoid, farnesal (2) and the viscidane diterpenoid, 5 alpha-hydroxyviscida-3,14-dien-20-oic acid (3). The purified compounds were tested for antibacterial activity with 2 and 3 showing moderate antibacterial activity against Gram-positive bacteria.

引用

页数：8

共 31 条

[1] Antibacterial spectrum and cytotoxic activities of serrulatane compounds from the Australian medicinal plant Eremophila neglecta [J].

Anakok, O. F. ;

Ndi, C. P. ;

Barton, M. D. ;

Griesser, H. J. ;

Semple, S. J. .

JOURNAL OF APPLIED MICROBIOLOGY, 2012, 112 (01) :197-204

[2] Antibacterial serrulatane diterpenes from the Australian native plant Eremophila microtheca [J].

Barnes, Emma C. ;

Kavanagh, Angela M. ;

Ramu, Soumya ;

Blaskovich, Mark A. ;

Cooper, Matthew A. ;

Davis, Rohan A. .

PHYTOCHEMISTRY, 2013, 93 :162-169

[3] Antibacterial constituents of Eremophila alternifolia: An Australian aboriginal traditional medicinal plant [J].

Biva, Israt J. ;

Ndi, Chi P. ;

Griesser, Hans J. ;

Semple, Susan J. .

JOURNAL OF ETHNOPHARMACOLOGY, 2016, 182 :1-9

[4]

Brophy JJ, 1999, FLAVOUR FRAG J, V14, P98, DOI 10.1002/(SICI)1099-1026(199903/04)14:2<98::AID-FFJ797>3.0.CO

[5]

2-V

[6]

Chinnock R.J., 2007, Eremophila and allied genera: a monograph of the plant family Myoporaceae

[7] VISCIDANE DITERPENES FROM EREMOPHILA SPECIES [J].

FORSTER, PG ;

GHISALBERTI, EL ;

JEFFERIES, PR .

PHYTOCHEMISTRY, 1993, 32 (05) :1225-1228

[8] Antibacterial Nerol Cinnamates from the Australian Plant Eremophila longifolia [J].

Galappathie, Savithri ;

Edwards, David J. ;

Elliott, Alysha G. ;

Cooper, Matthew A. ;

Palombo, Enzo A. ;

Butler, Mark S. ;

Mahon, Peter J. .

JOURNAL OF NATURAL PRODUCTS, 2017, 80 (04) :1178-1181

[9]

Ghisalberti E.L., 1995, STUD NAT PROD CHEM, V15, P225, DOI DOI 10.1016/S1572-5995(06)80133-X

[10] THE CHEMISTRY OF EREMOPHILA SPP .25. NEW CEMBRENE DERIVATIVES FROM EREMOPHILA-DEMPSTERI, EREMOPHILA-PLATYCALYX AND EREMOPHILA-FRASERI [J].

GHISALBERTI, EL ;

JEFFERIES, PR ;

MORI, TA .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1986, 39 (10) :1703-1710

← 1 2 3 4 →