Synthesis, transformation and antibacterial activity of new N,N-disubstituted 2-aminothiazole derivatives

被引：0

作者：

Grybaite, Birute ^{[1
]}

Jonuskiene, Ilona ^{[1
]}

Vaickelioniene, Rita ^{[1
]}

Mickevicius, Vytautas ^{[1
]}

机构：

[1] Kaunas Univ Technol, Dept Organ Chem, Radvilenu Rd 19, LT-50254 Kaunas, Lithuania

来源：

CHEMIJA | 2017年 / 28卷 / 01期

关键词：

thiazole; 4-quinolone; biological activity; pharmaceuticals; AGENTS; INHIBITORS; POTENT; 2-PHENYL-4-QUINOLONE; IDENTIFICATION; CYTOTOXICITY; THIAZOLE; DESIGN; SERIES; ACIDS;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of novel N,N-disubstituted 2-aminothiazole derivatives were synthesized by the Hantzsch reaction from 3-[(1-naphthyl) carbamothioylamino] propanoic acid and alpha-halocarbonyl compounds. With the help of various chemical transformations of the obtained compounds, new variously functionalized 2-aminothiazole derivatives were synthesized. Some of them were tested for their antibacterial properties against gram-negative non-spore-forming rods of Rhizobium radiobacter.

引用

页码：64 / 73

页数：10

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