PSCA rs2294008 polymorphism contributes to the decreased risk for cervical cancer in a Chinese population

被引：14

作者：

Wang, Shizhi ^{[1
]}

Wu, Shenshen ^{[1
]}

Zhu, Haixia ^{[2
]}

Ding, Bo ^{[3
]}

Cai, Yunlang ^{[3
]}

Ni, Jing ^{[4
]}

Wu, Qiang ^{[4
]}

Meng, Qingtao ^{[1
]}

Zhang, Xin ^{[1
]}

Zhang, Chengcheng ^{[1
]}

Li, Xiaobo ^{[1
]}

Wang, Meilin ^{[5
]}

Chen, Rui ^{[1
]}

Jin, Hua ^{[2
]}

Zhang, Zhengdong ^{[5
,6
]}

机构：

[1] Southeast Univ, Sch Publ Hlth, Minist Educ, Key Lab Environm Med Engn, Nanjing, Jiangsu, Peoples R China

[2] Nantong Tumor Hosp, Core Lab, Nantong, Peoples R China

[3] Southeast Univ, Sch Med, Zhongda Hosp, Dept Gynecol & Obstet, Nanjing, Jiangsu, Peoples R China

[4] Nanjing Med Univ, Affiliated Canc Hosp, Jiangsu Canc Hosp, Dept Gynecol Oncol, Nanjing, Jiangsu, Peoples R China

[5] Nanjing Med Univ, Ctr Canc, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Dept Environm Genom, Nanjing, Jiangsu, Peoples R China

[6] Nanjing Med Univ, Sch Publ Hlth, Minist Educ, Dept Genet Toxicol,Key Lab Modern Toxicol, Nanjing, Jiangsu, Peoples R China

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

STEM-CELL ANTIGEN; GENETIC-VARIATION; GASTRIC-CANCER; BLADDER; SUSCEPTIBILITY; EXPRESSION; ASSOCIATION; TUMOR;

D O I：

10.1038/srep23465

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recently, three genome-wide association studies have identified the PSCA (prostate stem cell antigen) rs2294008 polymorphism (C > T) associated with susceptibility to gastric cancer, bladder cancer, and duodenal ulcers, highlighting its critical role in disease pathogenesis. Given PSCA is reported to be overexpressed in cervical cancer and the rs2294008 can influence PSCA transcription, we aimed to determine the role of rs2294008 in susceptibility to cervical cancer. The genotyping was performed in the 1126 cases and 1237 controls. Our results showed the rs2294008 TT genotype significantly associated with a reduced risk of cervical cancer (adjusted OR = 0.55, 95% CI = 0.38-0.79; recessive model). Stratified analyses revealed that the association was restricted to the subgroups of age > 49 years, parity <= 1, abortion and early-stage cervical cancer. Immunohistochemistry assay showed the individuals carrying the TT genotype having lower PSCA expression than those with CC/CT genotypes. In summary, the PSCA rs2294008 polymorphism may serve as a biomarker of cervical cancer, particularly of early-stage cervical cancer.

引用

页数：7

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