A review of Nigella sativa plant-based therapy in dermatology

被引:12
作者
Hwang, Jacqueline R. [1 ]
Cartron, Alexander M. [1 ]
Khachemoune, Amor [2 ,3 ]
机构
[1] Univ Maryland, Sch Med, Baltimore, MD 21201 USA
[2] Vet Affairs Med Ctr, Brooklyn, NY USA
[3] SUNY Downstate, Brooklyn, NY USA
关键词
ATOPIC-DERMATITIS; SEED OIL; THYMOQUINONE; SUPPLEMENTATION; CELLS; ENHANCEMENT; ACTIVATION; MECHANISMS; EXPRESSION; APOPTOSIS;
D O I
10.1111/ijd.15615
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Nigella sativa (N. sativa) is a widely used medicinal herb with a rich cultural and religious history in Unani, Ayurveda, Chinese, and Arabic medicine. N. sativa contains many natural bioactive agents including alkaloids, saponins, alpha-hederin, and thymoquinone that contribute to its broad range of benefits as a diuretic, bronchodilator, antihypertensive, antidiabetic, and analgesic. In addition, N. sativa possesses antimicrobial, anti-inflammatory, and antineoplastic effects, making it an interesting potential therapy for the treatment of dermatological conditions. This article reviews the current literature surrounding the pharmacological effects of N. sativa for the treatment of acne vulgaris, melanoma, vitiligo, atopic dermatitis, plaque psoriasis, and wound healing.
引用
收藏
页码:E493 / E499
页数:7
相关论文
共 45 条
[31]   Effect of Topical Application of Black Seed Oil on Imiquimod-Induced Psoriasis-like Lesions in the Thin Skin of Adult Male Albino Rats [J].
Okasha, Ebtsam F. ;
Bayomy, Naglaa A. ;
Abdelaziz, Eman Z. .
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY, 2018, 301 (01) :166-174
[32]   An analysis of FDA-approved drugs: natural products and their derivatives [J].
Patridge, Eric ;
Gareiss, Peter ;
Kinch, Michael S. ;
Hoyer, Denton .
DRUG DISCOVERY TODAY, 2016, 21 (02) :204-207
[33]   Effectiveness, Safety, and Tolerability of Powdered Nigella sativa (Kalonji) Seed in Capsules on Serum Lipid Levels, Blood Sugar, Blood Pressure, and Body Weight in Adults: Results of a Randomized, Double-Blind Controlled Trial [J].
Qidwai, Waris ;
Bin Hamza, Hasan ;
Qureshi, Riaz ;
Gilani, Anwar .
JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, 2009, 15 (06) :639-644
[34]   Thymoquinone inhibits cell proliferation through regulation of G1/S phase cell cycle transition in N-nitrosodiethylamine-induced experimental rat hepatocellular carcinoma [J].
Raghunandhakumar, Subramanian ;
Paramasivam, Arumugam ;
Senthilraja, Selvam ;
Naveenkumar, Chandrasekar ;
Asokkumar, Selvamani ;
Binuclara, John ;
Jagan, Sundaram ;
Anandakumar, Pandi ;
Devaki, Thiruvengadam .
TOXICOLOGY LETTERS, 2013, 223 (01) :60-72
[35]   The Role of Nigella sativa and Its Active Constituents in Learning and Memory [J].
Sahak, Mohamad Khairul Azali ;
Kabir, Nurul ;
Abbas, Ghulam ;
Draman, Suhaimi ;
Hashim, Noor Hashida ;
Adli, Durriyyah Sharifah Hasan .
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2016, 2016
[36]   Nigella sativa and Its Active Compound, Thymoquinone, Accelerate Wound Healing in an In Vivo Animal Model: A Comprehensive Review [J].
Sallehuddin, Nusaibah ;
Nordin, Abid ;
Idrus, Ruszymah Bt Hj ;
Fauzi, Mh Busra .
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2020, 17 (11) :1-17
[37]   INHIBITORY EFFECTS OF NIGELLA-SATIVA AND SAFFRON (CROCUS-SATIVUS) ON CHEMICAL CARCINOGENESIS IN MICE [J].
SALOMI, MJ ;
NAIR, SC ;
PANIKKAR, KR .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 1991, 16 (01) :67-72
[38]   Effectiveness of topical Nigella sativa for vitiligo treatment [J].
Sarac, Gulbahar ;
Kapicioglu, Yelda ;
Sener, Serpil ;
Mantar, Irem ;
Yologlu, Saim ;
Dundar, Cihat ;
Turkoglu, Murat ;
Pekmezci, Erkin .
DERMATOLOGIC THERAPY, 2019, 32 (04)
[39]   Targeting nuclear factor-κB activation pathway by thymoquinone:: Role in suppression of antiapoptotic gene products and enhancement of apoptosis (Publication with Expression of Concern. See vol. 16, pg. 1441, 2018) [J].
Sethi, Gautam ;
Ahn, Kwang Seok ;
Aggarwal, Bharat B. .
MOLECULAR CANCER RESEARCH, 2008, 6 (06) :1059-1070
[40]   Cardiovascular Benefits of Black Cumin (Nigella sativa) [J].
Shabana, Adel ;
El-Menyar, Ayman ;
Asim, Mohammad ;
Al-Azzeh, Hiba ;
Al Thani, Hassan .
CARDIOVASCULAR TOXICOLOGY, 2013, 13 (01) :9-21