Stachybotranes A-D, phenylspirodrimanes from the wetland fungus Stachybotrys chartarum with cytotoxic activities

被引：3

作者：

Bao, Yan-Ru ^{[1
,2
]}

Feng, Han-Lin ^{[2
]}

Yao, Xin-Sheng ^{[1
]}

机构：

[1] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangzhou, Peoples R China

[2] Shenzhen Neptunus Med Sci & Technol Res Inst Co L, Inst Nat Prod, Shenzhen, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2022年 / 36卷 / 15期

关键词：

Stachybotrys chartarum; wetland fungus; phenylspirodrimanes; cytotoxic activity;

D O I：

10.1080/14786419.2021.1896510

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Four new phenylspirodrimanes, stachybotranes A-D (1-4), along with seven known analogues (5-11), were isolated from the extract of a wetland fungal strain Stachybotrys chartarum DTH12-9. The structures of new compounds were determined by spectroscopic analyses, X-ray crystallographic analysis, and the CD analysis of the in situ formed [Rh-2(OCOCF3)(4)] complex. Compounds 1-3, 5-8, and 10 were evaluated for in vitro cytotoxicity against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7, and SW-480. Compounds 1, 2, and 7 exhibited moderate cytotoxic potency against various human cancer cell lines.

引用

页码：3894 / 3900

页数：7

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