FEZ1/LZTS1 Protein Expression in Ovarian Cancer

被引：17

作者：

Califano, Daniela ^{[1
]}

Pignata, Sandro ^{[1
]}

Pisano, Carmela ^{[1
]}

Greggi, Stefano ^{[1
]}

Laurelli, Giuseppe ^{[1
]}

Losito, Nunzia Simona ^{[1
]}

Ottaiano, Alessandro ^{[1
]}

Gallipoli, Adolfo ^{[1
]}

Pasquinelli, Rosa ^{[1
]}

De Simone, Veronica ^{[2
]}

Cirombella, Roberto ^{[3
]}

Fusco, Alfredo ^{[4
]}

Chiappetta, Gennaro ^{[1
]}

机构：

[1] Ist Nazl Tumori, Naples, Italy

[2] CROM, Avellino, Italy

[3] Univ Roma La Sapienza, Osped St Andrea, Fac Med 2, Div Anat Patol, Rome, Italy

[4] CNR, Ist Endocrinol & Oncol Sperimentale, I-80125 Naples, Italy

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2010年 / 222卷 / 02期

关键词：

TUMOR-SUPPRESSOR; CELL-CARCINOMA; GENE; CYCLOPHOSPHAMIDE; PACLITAXEL; CISPLATIN; MITOSIS; TRIAL; WOMEN;

D O I：

10.1002/jcp.21962

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The FEZI/LZTS/(FEZI) gene maps to chromosome 8p22 and is frequently altered in human cancer. FEZI has been proposed as a candidate tumour suppressor gene and its loss may contribute to tumour progression. We have analysed the expression of FEZI protein in tissues from ovarian carcinomas in relation to clinico-pathological variables, response to chemotherapy and disease-free and overall survival. FEZI status was assessed by immunohistochernistry. Cytoplasmic staining for FEZI protein was absent or drastically reduced in 38% of turnours. FEZI protein expression was not related to tumour grade, histotype, disease-free survival, or overall survival. On the contrary, it was significantly correlated with age and with FIGO stage of disease. This finding indicates that FEZI is involved in ovarian carcinogenesis. Moreover, loss of FEZI protein significantly predicted a complete treatment response in patients who received taxane-based chemotherapy. In conclusion, the reduction or loss of FEZI protein could be an aid to the clinical management of patients affected by ovarian carcinoma. J. Cell. Physiol. 222: 382-386, 2010. (C) 2009 Wiley-Liss, Inc.

引用

页码：382 / 386

页数：5

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