Improved stereoselectivity in intramolecular SN2′ cyclization through use of mechanistic principles

被引：3
|
作者：
Seo, Woo Duck [1 ]
Curtis-Long, Marcus J. [1 ]
Jeong, Seong Hun [1 ]
Jun, Tae Hong [1 ]
Yang, Min Suk [1 ]
Park, Ki Hun [1 ]
机构：
[1] Gyeongsang Natl Univ, Dept Agr Chem, Inst Agr & Life Sci, Div Appl Life Sci,BK Program 21, Jinju 660701, South Korea
来源：
SYNTHESIS-STUTTGART | 2007年 / 02期
基金：
日本学术振兴会;
关键词：
oxazolidin-2-one; intramolecular cyclization; stereoselectivity; A(1,3) strain; alpha-hydroxy-beta-amino acids;
D O I：
10.1055/s-2006-958956
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Valine and alanine were converted into the corresponding alpha-hydroxy-beta-amino acids through intramolecular S(N)2' cyclization. The novel cyclization protocol relied upon the use of N-benzyl-protected carbarnates derived from a-amino acids
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页码：209 / 214
页数：6
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