Nordihydroguaiaretic Acid Analogues: Their Chemical Synthesis and Biological Activities

被引：21

作者：

Chen, Qingqi ^{[1
,2
]}

机构：

[1] MedKoo Biosci Inc, Chapel Hill, NC 27516 USA

[2] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 17期

关键词：

Nordihydroguaiaretic acid; NDGA derivatives; terameprocol; survivin inhibitors; lignan; diarylbutanes; anticancers; anti-HIV; TRANSCRIPTION INHIBITOR; ANTICANCER ACTIVITY; LARREA-TRIDENTATA; BIOACTIVE DIBENZYLBUTYROLACTONE; ASYMMETRIC-SYNTHESIS; ANTIVIRAL ACTIVITIES; FURAMIDINE ANALOGS; SAURURUS-CHINENSIS; CREOSOTE BUSH; SAUCERNEOL-B;

D O I：

10.2174/156802609789941915

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nordihydroguaiaretic acid is a natural occurring lignan mainly isolated and commercially produced from desert plant, creosote bush (Larrea divaricata Cav. Or Corillea tridentate), which can be widely found in the border zone of southern of USA and northern of Mexico. During past 100 years, extensive research has demonstrated that nordihydroguaiaretic acid and its synthetic analogues are potentially useful in treating diseases related to cancers, diabetes, viral, bacterial infections, and inflammation. Remarkably, terameprocol, a tetra-O-methyl derivative of nordihydroguaiaretic acid, is currently in Phase I/II clinical trials as an anticancer agent. This review deals with the chemical synthesis and bioactivities of nordihydroguaiaretic acid and its structurally-related derivatives, which possess anticancer, antioxidant, antimicrobial, anti-inflammatory and immunosuppressive activities. The review consists of the data reported in over 100 publications.

引用

页码：1636 / 1659

页数：24

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