The Relationship between Inflammation and Regeneration in the MRL Mouse Potential Relevance for Putative Human Regenerative (Scarless Wound Healing) Capacities?

被引：25

作者：

Heber-Katz, Ellen ^{[1
]}

Gourevitch, Dmitri ^{[1
]}

机构：

[1] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

来源：

LONGEVITY, REGENERATION, AND OPTIMAL HEALTH: INTEGRATING EASTERN AND WESTEN PERSPECTIVES | 2009年 / 1172卷

关键词：

basement membrane; blastema; inflammation; MRL mouse; matrix metalloproteinases; neutrophils; regeneration; cognitive-behavioral; meditation; MATRIX-METALLOPROTEINASE ACTIVITY; NEWT TRITURUS VIRIDESCENS; LIMB REGENERATION; COLLAGENOLYTIC ACTIVITY; SPINAL-CORD; MICE; EXPRESSION; BLASTEMA; FETAL; MORPHOGENESIS;

D O I：

10.1111/j.1749-6632.2009.04499.x

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

The matrix metalloproteinases (MMPs) have been implicated in the regenerative response in amphibians and various mammalian models of regeneration. The neutrophil response is known to bring MMPs and other proteases to the wound to promote bacterial elimination and tissue remodeling. These issues in relation to what is occurring in the MRL mouse model of regeneration/wound healing are discussed, followed. by speculation as to their possible relevance for examples of the putative scarless wound healing described by some medical anthropologists and clinicians.

引用

页码：110 / 114

页数：5

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