Role of immune cells in obesity induced low grade inflammation and insulin resistance

被引：206

作者：

Asghar, Ambreen ^{[1
]}

Sheikh, Nadeem ^{[1
]}

机构：

[1] Univ Punjab, Dept Zool, Cell & Mol Biol Lab, Q-A Campus, Lahore 54590, Pakistan

来源：

CELLULAR IMMUNOLOGY | 2017年 / 315卷

关键词：

Adipose tissues; Immune cells; Inflammation; Insulin resistance; Obesity; NECROSIS-FACTOR-ALPHA; ADIPOSE-TISSUE INFLAMMATION; REGULATORY T-CELLS; MONOCYTE CHEMOATTRACTANT PROTEIN-1; FATTY-ACID OXIDATION; DIET-INDUCED OBESITY; TNF-ALPHA; RECEPTOR SUBSTRATE-1; WEIGHT-LOSS; MAST-CELLS;

D O I：

10.1016/j.cellimm.2017.03.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The frequency of obesity is enormously growing worldwide. Obesity results when energy intake exceeds, energy expenditure. Excess adiposity is a major risk factor in the progress of various metabolic disorders accounting insulin resistance, hypertension, Type 2 diabetes, nonalcoholic fatty liver disease, polycystic ovarian disease and several types of cancers. Obesity is characterized by pro-inflammatory condition in which hypertrophied adipose tissue along with immune cells contribute to increase the level of pro-inflammatory cytokines. Immune cells are the key players in inducing low grade chronic inflammation in obesity and are main factor responsible for pathogenesis of insulin resistance resulting Type 2 diabetes. The current review is aimed to investigate the mechanism of pro-inflammatory responses and insulin resistance involving immune cells and their products in obesity. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：18 / 26

页数：9

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