CLEC9A is a novel activation C-type lectin-like receptor expressed on BDCA3+ dendritic cells and a subset of monocytes

被引：254

作者：

Huysamen, Cristal ^{[1
]}

Willment, Janet A. ^{[1
]}

Dennehy, Kevin M. ^{[1
]}

Brown, Gordon D. ^{[1
]}

机构：

[1] Univ Cape Town, Div Immunol, Inst Infect Dis & Mol Med, ZA-7925 Cape Town, South Africa

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2008年 / 283卷 / 24期

基金：

英国惠康基金;

关键词：

D O I：

10.1074/jbc.M709923200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe here the first characterization of CLEC9A, a group V C-type lectin-like receptor located in the "Dectin-1 cluster" of related receptors, which are encoded within the natural killer (NK)-gene complex. Expression of human CLEC9A is highly restricted in peripheral blood, being detected only on BDCA3(+) dendritic cells and on a small subset of CD14(+) CD16(-) monocytes. CLEC9A is expressed at the cell surface as a glycosylated dimer and can mediate endocytosis, but not phagocytosis. CLEC9A possesses a cytoplasmic immunoreceptor tyrosine-based activation-like motif that can recruit Syk kinase, and we demonstrate, using receptor chimeras, that this receptor can induce proinflammatory cytokine production. These data indicate that CLEC9A functions as an activation receptor.

引用

页码：16693 / 16701

页数：9

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