Redox-Responsive Drug Delivery Systems: A Chemical Perspective

被引：54
作者：
Abed, Heba F. [1 ]
Abuwatfa, Waad H. [2 ,3 ]
Husseini, Ghaleb A. [2 ,3 ]
机构：
[1] Amer Univ Sharjah, Dept Biol Chem & Environm Sci, POB 26666, Sharjah, U Arab Emirates
[2] Amer Univ Sharjah, Coll Engn, Dept Chem Engn, POB 26666, Sharjah, U Arab Emirates
[3] Amer Univ Sharjah, Coll Arts & Sci, Mat Sci & Engn Program, POB 26666, Sharjah, U Arab Emirates
来源：
NANOMATERIALS | 2022年 / 12卷 / 18期
关键词：
drug delivery systems; redox-responsive; reducing; linkers; bonds; CROSS-LINKED MICELLES; HYALURONIC-ACID NANOGELS; FUNCTIONALIZED LIPOSOMES; POLYPEPTIDE NANOGEL; GLUTATHIONE; CANCER; NANOPARTICLES; HYDROGELS; THERAPY; RELEASE;
D O I：
10.3390/nano12183183
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
With the widespread global impact of cancer on humans and the extensive side effects associated with current cancer treatments, a novel, effective, and safe treatment is needed. Redox-responsive drug delivery systems (DDSs) have emerged as a potential cancer treatment with minimal side effects and enhanced site-specific targeted delivery. This paper explores the physiological and biochemical nature of tumors that allow for redox-responsive drug delivery systems and reviews recent advances in the chemical composition and design of such systems. The five main redox-responsive chemical entities that are the focus of this paper are disulfide bonds, diselenide bonds, succinimide-thioether linkages, tetrasulfide bonds, and platin conjugates. Moreover, as disulfide bonds are the most commonly used entities, the review explored disulfide-containing liposomes, polymeric micelles, and nanogels. While various systems have been devised, further research is needed to advance redox-responsive drug delivery systems for cancer treatment clinical applications.
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页数：26
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