New insights into molecular mechanisms of epigenetic regulation in kidney disease

被引:15
作者
Mimura, Imari [1 ]
Tanaka, Tetsuhiro [1 ]
Nangaku, Masaomi [1 ]
机构
[1] Univ Tokyo, Div Nephrol & Endocrinol, Tokyo, Japan
基金
日本学术振兴会;
关键词
chromosome conformation; epigenetic memory; hypoxia; EPIGENOME-WIDE ASSOCIATION; HYPOXIA PROMOTES FIBROGENESIS; LONG NONCODING RNAS; TUBULOINTERSTITIAL INJURY; DNA METHYLATION; RENAL FIBROSIS; INDUCIBLE FACTOR; GENOME SEQUENCE; INDOXYL SULFATE; CHIP-SEQ;
D O I
10.1111/1440-1681.12663
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The number of patients with kidney failure has increased in recent years. Different factors contribute to the progression of chronic kidney disease, including glomerular sclerosis, atherosclerosis of the renal arteries and tubulointerstitial fibrosis. Tubulointerstitial injury is induced by hypoxia and other inflammatory signals, leading to fibroblast activation. Technological advances using high-throughput sequencing has enabled the determination of the expression profile of almost all genes, revealing that gene expression is intricately regulated by DNA methylation, histone modification, changes in chromosome conformation, long non-coding RNAs and microRNAs. These epigenetic modifications are stored as cellular epigenetic memory. Epigenetic memory leads to adult-onset disease or ageing in the long term and may possibly play an important role in the kidney disease process. Herein we emphasize the importance of clarifying the molecular mechanisms underlying epigenetic modifications because this may lead to the development of new therapeutic targets in kidney disease.
引用
收藏
页码:1159 / 1167
页数:9
相关论文
共 103 条
[1]   The functions of animal microRNAs [J].
Ambros, V .
NATURE, 2004, 431 (7006) :350-355
[2]   CpG islands as genomic footprints of promoters that are associated with replication origins [J].
Antequera, F ;
Bird, A .
CURRENT BIOLOGY, 1999, 9 (17) :R661-R667
[3]   Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice [J].
Asada, Nariaki ;
Takase, Masayuki ;
Nakamura, Jin ;
Oguchi, Akiko ;
Asada, Misako ;
Suzuki, Norio ;
Yamarnura, Ken-ichi ;
Nagoshi, Narihito ;
Shibata, Shinsuke ;
Rao, Tata Nageswara ;
Fehling, Hans Joerg ;
Fukatsu, Atsushi ;
Minegishi, Naoko ;
Kita, Toru ;
Kimura, Takeshi ;
Okano, Hideyuki ;
Yamamoto, Masayuki ;
Yanagita, Motoko .
JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (10) :3981-3990
[4]   Epidemiology and management of end-stage renal disease in the elderly [J].
Brown, Edwina A. ;
Johansson, Lina .
NATURE REVIEWS NEPHROLOGY, 2011, 7 (10) :591-598
[5]   RNA-Seq defines novel genes, RNA processing patterns and enhancer maps for the early stages of nephrogenesis: Hox supergenes [J].
Brunskill, Eric W. ;
Potter, S. Steven .
DEVELOPMENTAL BIOLOGY, 2012, 368 (01) :4-17
[6]   Role of histone H3 lysine 27 methylation in polycomb-group silencing [J].
Cao, R ;
Wang, LJ ;
Wang, HB ;
Xia, L ;
Erdjument-Bromage, H ;
Tempst, P ;
Jones, RS ;
Zhang, Y .
SCIENCE, 2002, 298 (5595) :1039-1043
[7]   RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond [J].
Castel, Stephane E. ;
Martienssen, Robert A. .
NATURE REVIEWS GENETICS, 2013, 14 (02) :100-112
[8]   Hyperfiltration in African-American patients with type 2 diabetes - Cross-sectional and longitudinal data [J].
Chaiken, RL ;
Eckert-Norton, M ;
Bard, M ;
Banerji, MA ;
Palmisano, J ;
Sachimechi, I ;
Lebovitz, HE .
DIABETES CARE, 1998, 21 (12) :2129-2134
[9]   Independence of Repressive Histone Marks and Chromatin Compaction during Senescent Heterochromatic Layer Formation [J].
Chandra, Tamir ;
Kirschner, Kristina ;
Thuret, Jean-Yves ;
Pope, Benjamin D. ;
Ryba, Tyrone ;
Newman, Scott ;
Ahmed, Kashif ;
Samarajiwa, Shamith A. ;
Salama, Rafik ;
Carroll, Thomas ;
Stark, Rory ;
Janky, Rekin's ;
Narita, Masako ;
Xue, Lixiang ;
Chicas, Agustin ;
Nunez, Sabrina ;
Janknecht, Ralf ;
Hayashi-Takanaka, Yoko ;
Wilson, Michael D. ;
Marshall, Aileen ;
Odom, Duncan T. ;
Babu, M. Madan ;
Bazett-Jones, David P. ;
Tavare, Simon ;
Edwards, Paul A. W. ;
Lowe, Scott W. ;
Kimura, Hiroshi ;
Gilbert, David M. ;
Narita, Masashi .
MOLECULAR CELL, 2012, 47 (02) :203-214
[10]   STUDIES ON ROLE OF HOST IMMUNE-RESPONSE IN RECOVERY FROM FRIEND VIRUS LEUKEMIA .1. ANTIVIRAL AND ANTILEUKEMIA CELL ANTIBODIES [J].
CHESEBRO, B ;
WEHRLY, K .
JOURNAL OF EXPERIMENTAL MEDICINE, 1976, 143 (01) :73-84