Analgesic activity of the aqueous seed extract of Hunteria umbellata (K. Schum.) Hallier f. in rodents

被引：0
|
作者：
Adeyemi, Olufunmilayo Olaide [1 ]
Adeneye, Adejuwon Adewale [1 ,2 ]
Alabi, Tope Elizabeth [1 ]
机构：
[1] Univ Lagos, Coll Med, Fac Basic Med Sci, Dept Pharmacol, Idi Araba, Lagos State, Nigeria
[2] Lagos State Univ, Coll Med, Fac Basic Med Sci, Dept Pharmacol, Ikeja, Lagos State, Nigeria
来源：
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY | 2011年 / 49卷 / 09期
关键词：
Analgesic activity; Aqueous seed extract; Hunteria umbellata; Rodents; FORMALIN TEST; PAIN; ANTAGONISTS; HEADACHE; ANIMALS; RAT;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The analgesic effect and possible mechanism(s) of action of 50-200 mg/kg of the aqueous seed extract of H. umbellata (HU) were investigated in different experimental models of analgesia using the tail flick, tail immersion, acetic acid-induced writhing tests and formalin-induced algesia. Oral pre-treatment with 50-200 mg/kg of HU caused significant and dose related analgesic effect in the treated rats in all the experimental models used. This analgesia was mediated via central and peripheral mechanisms. Overall, the results showed that HU possesses analgesic effect which lends support to its folkloric use in the local management of pain.
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页码：698 / 703
页数：6
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