Successful double bypass in a patient with severe hemophilia A: a case report

被引：7

作者：

Barillari, Giovanni ^{[1
]}

Pasca, Samantha ^{[1
]}

Erice, Filippo ^{[2
]}

Livi, Ugolino ^{[3
]}

机构：

[1] Univ Hosp, Ctr Hemorrhag & Thrombot Dis, I-33100 Udine, Italy

[2] Univ Hosp, Anesthesia & Resuscitat Dept, I-33100 Udine, Italy

[3] Univ Hosp, Dept Cardiac Surg, I-33100 Udine, Italy

来源：

JOURNAL OF THROMBOSIS AND THROMBOLYSIS | 2012年 / 33卷 / 02期

关键词：

Cardiovascular surgery; Hemophilia A; Haemostasis; FVIII replacement; FACTOR-VIII; INHIBITOR DEVELOPMENT; CARDIAC-SURGERY;

D O I：

10.1007/s11239-011-0664-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Life expectancy in the hemophilia people is similar to the non-haemophilics and age-related cardiovascular disorders to become more prevalent, but cardiac surgery is considered a very high risk for these patients. In this article we report the successful cardiac double bypass internal mammary artery-coronary artery in a patient with severe hemophilia A. (FVIII < 1%; missense mutation: exon 16, c.5508 G > A (domain A3), p.Trp1817Stop). Continuous infusion of rFVIII B-domain deleted was used to control haemostasis during surgery and in post-operative period. There was no bleeding complications and the patient did not need to receive transfusion of red blood cells or platelets.

引用

页码：193 / 196

页数：4

共 10 条

[1] Cardiac surgery in a patient with haemophilia A [J].

Eren, A. ;

Friedl, R. ;

Hannekum, A. ;

Gulbins, H. .

THORACIC AND CARDIOVASCULAR SURGEON, 2006, 54 (03) :212-214

[2] Prevention of venous thromboembolism [J].

Geerts, William H. ;

Bergqvist, David ;

Pineo, Graham F. ;

Heit, John A. ;

Samama, Charles M. ;

Lassen, Michael R. ;

Colwell, Clifford W. .

CHEST, 2008, 133 (06) :381S-453S

[3] Influence of the type of F8 gene mutation on inhibitor development in a single centre cohort of severe haemophilia A patients [J].

Gouw, S. C. ;

Van der Bom, J. G. ;

Van den Berg, H. M. ;

Zewald, R. A. ;

Van Amstel, J. K. Ploos ;

Mauser-Bunschoten, E. P. .

HAEMOPHILIA, 2011, 17 (02) :275-281

[4] Tranexamic acid combined with recombinant factor VIII increases clot resistance to accelerated fibrinolysis in severe hemophilia A [J].

Hvas, A. -M. ;

Sorensen, H. T. ;

Norengaard, L. ;

Christiansen, K. ;

Ingerslev, J. ;

Sorensen, B. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2007, 5 (12) :2408-2414

[5] Transient acquired hemophilia associated with Mycoplasma pneumoniae pneumonia [J].

Kim, Min Sun ;

Kilgore, Paul E. ;

Kang, Ju Sung ;

Kim, Sun Young ;

Lee, Dae Yeol ;

Kim, Jung Soo ;

Hwang, Pyoung Han .

JOURNAL OF KOREAN MEDICAL SCIENCE, 2008, 23 (01) :138-141

[6] CORONARY ARTERY BYPASS SURGERY, ANGIOPLASTY AND LONG TERM ANTI-PLATELET TREATMENT IN A TYPE B HEMOPHILIA PATIENT [J].

Pesaro, Antonio Eduardo ;

Gaz, Marcus Vinicius ;

Karbstein, Ralf ;

Perin, Marco ;

Serrano, Carlos Vicente, Jr. ;

Damico, Elbio .

CLINICS, 2009, 64 (08) :822-823

[7] Intensive exposure to factor VIII is a risk factor for inhibitor development in mild hemophilia A [J].

Sharathkumar, A ;

Lillicrap, D ;

Blanchette, VS ;

Kern, M ;

Leggo, J ;

Stain, AM ;

Brooker, L ;

Carcao, MD .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2003, 1 (06) :1228-1236

[8] Continuous infusion of B-domain deleted recombinant factor VIII (ReFacto) in patients with haemophilia A undergoing surgery:: clinical experience [J].

Stieltjes, N ;

Altisent, C ;

Auerswald, G ;

Négrier, C ;

Pouzol, P ;

Reynaud, J ;

Roussel-Robert, V ;

Savidge, GF ;

Villar, A ;

Schulman, S .

HAEMOPHILIA, 2004, 10 (05) :452-458

[9] Cardiac surgery in patients with haemophilia [J].

Tang, M. ;

Wierup, P. ;

Terp, K. ;

Ingerslev, J. ;

Sorensen, B. .

HAEMOPHILIA, 2009, 15 (01) :101-107

[10]

*WFH, 2005, GUID MAN HAEM

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