Intestinal Microbiota Remodeling Protects Mice from Western Diet-Induced Brain Inflammation and Cognitive Decline

被引:21
作者
Jena, Prasant Kumar [1 ,2 ]
Setayesh, Tahereh [1 ]
Sheng, Lili [1 ]
Di Lucente, Jacopo [1 ]
Jin, Lee Way [1 ]
Wan, Yu-Jui Yvonne [1 ]
机构
[1] Univ Calif Davis, Dept Med Pathol & Lab Med, Sacramento, CA 95817 USA
[2] Cedars Sinai Med Ctr, Dept Pediat, Los Angeles, CA 90048 USA
关键词
gut microbiota; bile acid receptor; neuroplasticity; brain inflammation; metabolomics; Bifidobacterium infantis; BILE-ACIDS; INSULIN-RESISTANCE; ALZHEIMERS; CERAMIDE; MEMORY; NEURODEGENERATION; CHOLESTEROL; INHIBITION; NEURONS; PATHWAY;
D O I
10.3390/cells11030504
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
It has been shown that the Western diet (WD) induces systemic inflammation and cognitive decline. Moreover, probiotic supplementation and antibiotic treatment reduce diet-induced hepatic inflammation. The current study examines whether shaping the gut microbes by Bifidobacterium infantis (B. infantis) supplementation and antibiotic treatment reduce diet-induced brain inflammation and improve neuroplasticity. Furthermore, the significance of bile acid (BA) signaling in regulating brain inflammation was studied. Mice were fed a control diet (CD) or WD for seven months. B. infantis was supplemented to WD-fed mice to study brain inflammation, lipid, metabolomes, and neuroplasticity measured by long-term potentiation (LTP). Broad-spectrum coverage antibiotics and cholestyramine treatments were performed to study the impact of WD-associated gut microbes and BA in brain inflammation. Probiotic B. infantis supplementation inhibited diet-induced brain inflammation by reducing IL6, TNF alpha, and CD11b levels. B. infantis improved LTP and increased brain PSD95 and BDNF levels, which were reduced due to WD intake. Additionally, B. infantis reduced cecal cholesterol, brain ceramide and enhanced saturated fatty acids. Moreover, antibiotic treatment, as well as cholestyramine, diminished WD-induced brain inflammatory signaling. Our findings support the theory that intestinal microbiota remodeling by B. infantis reduces brain inflammation, activates BA receptor signaling, and improves neuroplasticity.
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页数:16
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