Hydrogen Peroxide Scavenging Activity of Novel Coumarins Synthesized Using Different Approaches

被引：59
作者：
Al-Amiery, Ahmed A. [1 ,2 ]
Al-Majedy, Yasameen K. [2 ]
Kadhum, Abdul Amir H. [2 ]
Mohamad, Abu Bakar [2 ,3 ]
机构：
[1] Univ Kebangsaan Malaysia, Dept Chem & Proc Engn, Bangi 43000, Selangor, Malaysia
[2] Univ Technol UOT, Environm Res Ctr, Baghdad 10001, Iraq
[3] Univ Kebangsaan Malaysia, Fuel Cell Inst, Bangi 43000, Selangor, Malaysia
来源：
PLOS ONE | 2015年 / 10卷 / 07期
关键词：
ANTIMICROBIAL ACTIVITY; DERIVATIVES;
D O I：
10.1371/journal.pone.0132175
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
New derivatives of 7-hydroxy-4-methylcoumarin were synthesized using a chemical method and a microwave-assisted method to compare the feasibility, reaction times, and yields of the product. The newly synthesized coumarins were characterized by different spectroscopic techniques (FT-IR and NMR) and micro-elemental analysis (CHNS). In vitro antioxidant activities of these compounds were evaluated against hydrogen peroxide and were compared with standard natural antioxidant, vitamin C. Our results reveal that these compounds exhibit excellent radical scavenging activities.
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页数：9
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