Protective effect of lignans against sepsis from the roots of Saururus chinensis

被引：45

作者：

Seo, Chang-Seob ^{[1
]}

Lee, Yeun-Kyung ^{[1
]}

Kim, Young-Jin ^{[1
]}

Jung, Jun-Sub ^{[2
]}

Jahng, Yurngdong ^{[1
]}

Chang, Hyun-Wook ^{[1
]}

Song, Dong-Keun ^{[2
]}

Son, Jong-Keun ^{[1
]}

机构：

[1] Yeungnam Univ, Coll Pharm, Kyongsan 712749, South Korea

[2] Hallym Univ, Coll Med, Inst Nat Med, Dept Pharmacol, Chunchon 200702, South Korea

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2008年 / 31卷 / 03期

关键词：

Saururus chinensis; sepsis; tumor necrosis factor-alpha; alanine aminotransferase activity;

D O I：

10.1248/bpb.31.523

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the course of isolating preventive agents from sepsis based on the in vivo assay model from the EtOAc extract of the roots of Saururus chinensis, twelve lignans, sarisan (1), erythro-austrobailignan-6 (2), meso-dihydroguaiaretic acid (3), saucerneol B (4), manassantin B (5), manassantin A (6), rel-(8R,8'R)-dimethyl-(7S,7'R)-bis(3,4-methylenedioxyphenyl)tetrahydro-furan (7), (+)-saururinone (8), sauchinone (9), sauchinone B (10), nectandrin B (11) and machilin D (12), were isolated. Compounds 9 and 10, at a dose of 10 mg/kg, increased survival rates to 80% from 20% for the control experiment, and decreased the plasma levels of tumor necrosis factor-alpha (TNF-alpha) and alanine aminotransferase (ALT) activity in mice administered LPS/D-GAlN.

引用

页码：523 / 526

页数：4

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