HIV-1 Entry Cofactor: Functional cDNA Cloing of a Seven-Transmembrane, G protein-Coupled Receptor

被引：3553
作者：
Feng, Yu [1 ]
Broder, Christopher C. [1 ]
Kennedy, Paul E. [1 ]
Berger, Edward A. [1 ]
机构：
[1] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA
来源：
JOURNAL OF IMMUNOLOGY | 2011年 / 186卷 / 11期
关键词：
VIRUS; FUSION; CELLS;
D O I：
10.1126/science.272.5263.872
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A cofactor for HIV-1 (human immunodeficiency virus-type 1) fusion and entry was identified with the use of a novel functional complementary DNA (cDNA) cloning strategy. This protein, designated "fusin," is a putative G protein-coupled receptor with seven transmembrane segments. Recombinant fusin enabled CD4-expressing nonhuman cell types to support HIV-1 Env-mediated cell fusion and HIV-1 infection. Antibodies to fusin blocked cell fusion and infection with normal CD4-positive human target cells. Fusin messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Fusin acted preferentially for T cell line-tropic isolates, in comparison to its activity with macrophage-tropic HIV-1 isolates.
引用
收藏
页码：872 / 877
页数：6
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