Cell migration: Rho GTPases lead the way

被引：1138
作者：
Raftopoulou, M
Hall, A
机构：
[1] UCL, MRC, Mol Cell Biol Lab, London WC1E 6BT, England
[2] UCL, Cell Biol Unit, Canc Res UK Ocogene & Signal Transduct Grp, London WC1E 6BT, England
[3] UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England
来源：
DEVELOPMENTAL BIOLOGY | 2004年 / 265卷 / 01期
基金：
英国医学研究理事会;
关键词：
cell migration; Rho GTPase; cell behavior;
D O I：
10.1016/j.ydbio.2003.06.003
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Rho GTPases control signal transduction pathways that link cell surface receptors to a variety of intracellular responses. They are best known as regulators of the actin cytoskeleton, but in addition they control cell polarity, gene expression, microtubule dynamics and vesicular trafficking. Through these diverse functions, Rho GTPases influence many aspects of cell behavior. This review will focus specifically on their role in cell migration. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码：23 / 32
页数：10
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