Combination echinocandin-polyene treatment of murine mucormycosis

被引：134
作者：
Ibrahim, Ashraf S. [1 ,2 ]
Gebremariam, Teclegiorgis [1 ]
Fu, Yue [1 ,2 ]
Edwards, John E., Jr. [1 ,2 ]
Spellberg, Brad [1 ,2 ]
机构：
[1] Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Div Infect Dis, Torrance, CA 90502 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 04期
关键词：
D O I：
10.1128/AAC.01458-07
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We previously found that caspofungin synergized with amphotericin B lipid complex in treating murine mucormycosis. We now report a similarly enhanced activity of liposomal amphotericin combined with micafungin or anidulafungin in mice with disseminated mucormycosis. The efficacy of combination echinocandin-polyene therapy for mucormycosis is a class effect.
引用
收藏
页码：1556 / 1558
页数：3
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