Combination echinocandin-polyene treatment of murine mucormycosis

被引：137

作者：

Ibrahim, Ashraf S. ^{[1
,2
]}

Gebremariam, Teclegiorgis ^{[1
]}

Fu, Yue ^{[1
,2
]}

Edwards, John E., Jr. ^{[1
,2
]}

Spellberg, Brad ^{[1
,2
]}

机构：

[1] Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Div Infect Dis, Torrance, CA 90502 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 04期

关键词：

D O I：

10.1128/AAC.01458-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We previously found that caspofungin synergized with amphotericin B lipid complex in treating murine mucormycosis. We now report a similarly enhanced activity of liposomal amphotericin combined with micafungin or anidulafungin in mice with disseminated mucormycosis. The efficacy of combination echinocandin-polyene therapy for mucormycosis is a class effect.

引用

页码：1556 / 1558

页数：3

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