3′-deoxy-3′-C-trifluoromethyl nucleosides:: Synthesis and antiviral evaluation

被引：13

作者：

Lavaire, S

Plantier-Royon, R

Portella, C

de Monte, M

Kirn, A

Aubertin, AM

机构：

[1] Univ Reims, CNRS, Unite Mixte Rech, Lab React Select & Applicat,UMR 6519,Fac Sci, F-51687 Reims 2, France

[2] Univ Strasbourg 1, INSERM U74, Inst Virol, Fac Med, F-67000 Strasbourg, France

来源：

NUCLEOSIDES & NUCLEOTIDES | 1998年 / 17卷 / 12期

关键词：

D O I：

10.1080/07328319808004316

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

2',3'-Dideoxy-3'-C-trifluoromethylthymidine 9a and -uridine 9b and 3'-C-trifluoromethyl-d(4)T 11 were prepared in a few steps from 3'-deoxy-3'-C-trifluoromethyl-D-ribose, which synthesis was recently reported. The biological assessment of these nucleoside analogues did not reveal interesting antiviral properties against HIV-1, HSV-1, CMV, Vaccine, and Cox B4.

引用

页码：2267 / 2280

页数：14

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