Total synthesis of the highly potent anti-HIV natural product daurichromenic acid along with its two chromane derivatives, rhododaurichromanic acids A and B

被引：97

作者：

Kang, Y ^{[1
]}

Mei, Y ^{[1
]}

Du, YG ^{[1
]}

Jin, ZD ^{[1
]}

机构：

[1] Univ Iowa, Coll Pharm, Div Med & Nat Prod Chem, Iowa City, IA 52242 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 23期

关键词：

D O I：

10.1021/ol030109m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The highly potent anti-HIV natural product daurichromenic acid was successfully synthesized in only five steps with 49% overall yield. The key step in the synthetic strategy involves a microwave-assisted tandem condensation and intramolecular S(N)2'-type cyclization to form the 2H-benzopyran core structure.

引用

页码：4481 / 4484

页数：4

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