Hypothalamic agrp and pomc mRNA Responses to Gastrointestinal Fullness and Fasting in Atlantic Salmon (Salmo salar, L.)

被引：33

作者：

Kalananthan, Tharmini ^{[1
]}

Murashita, Koji ^{[1
,2
]}

Ronnestad, Ivar ^{[1
]}

Ishigaki, Mitsumasa ^{[3
]}

Takahashi, Kota ^{[4
]}

Silva, Marta S. ^{[1
,5
]}

Wakabayashi, Yuki ^{[6
]}

Lai, Floriana ^{[1
]}

Shimizu, Munetaka ^{[6
]}

Nilsen, Tom O. ^{[1
,7
]}

Pino Martinez, Enrique ^{[1
,7
]}

Gomes, Ana S. ^{[1
]}

机构：

[1] Univ Bergen, Dept Biol Sci, Bergen, Norway

[2] Japan Fisheries Res & Educ Agcy, Natl Res Inst Aquaculture, Res Ctr Aquaculture Syst, Tamaki, Japan

[3] Nagoya Univ, Dept Anim Sci, Nagoya, Aichi, Japan

[4] Miyagi Univ Educ, Dept Biol, Sendai, Miyagi, Japan

[5] Inst Marine Res, Bergen, Norway

[6] Hokkaido Univ, Fac Fisheries Sci, Hakodate, Hokkaido, Japan

[7] NORCE Environm, Norwegian Res Ctr, Bergen, Norway

来源：

FRONTIERS IN PHYSIOLOGY | 2020年 / 11卷

关键词：

Atlantic salmon; hypothalamus; agrp; pomc; fullness; fasting; gastrointestinal tract; CENTRAL MELANOCORTIN SYSTEM; FOOD-INTAKE; TISSUE DISTRIBUTION; PROTEIN AGRP; AGOUTI-FAMILY; FISH; PROOPIOMELANOCORTIN; EXPRESSION; ZEBRAFISH; GROWTH;

D O I：

10.3389/fphys.2020.00061

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The orexigenic agouti-related protein (AgRP) and the anorexigenic pro-opiomelanocortin (POMC) are crucial players in the control of feed intake in vertebrates, yet their role in teleosts has not been fully established. Triplicate groups of Atlantic salmon (Salmo salar) post smolts were subjected to (1) fasting for 3 days (fast) and (2) normal feeding (fed), resulting in a significant (p < 0.05) upregulation of hypothalamic agrp1 transcripts levels in the fast group. Moreover, the mRNA abundance of agrp1 was significantly (p < 0.05) correlated with the stomach dry weight content. Corresponding inverse patterns were observed for pomca2, albeit not statistically significant. No significant differences were found for the other paralogues, agrp2 and pomca1 and b, between fed and fast groups. The significant correlation between stomach fullness and agrp1 mRNA expression suggests a possible link between the stomach filling/distension and satiety signals. Our study indicates that hypothalamic agrp1 acts as an orexigenic signal in Atlantic salmon.

引用

页数：8

共 46 条

[1]

[Anonymous], 2016, GGPLOT2 ELEGANT GRAP, DOI DOI 10.1007/978-3-319-24277-4

[2]

Castro MG, 1997, CRIT REV NEUROBIOL, V11, P35

[3] The central melanocortin system regulates food intake in goldfish [J].