Modulation of cell proliferation by heterotrimeric G protein in Arabidopsis

被引：291

作者：

Ullah, H

Chen, JG

Young, JC

Im, KH

Sussman, MR

Jones, AM

机构：

[1] Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA

[2] Univ Wisconsin, Cell & Mol Biol Program, Madison, WI 53706 USA

[3] Univ Wisconsin, Dept Hort, Madison, WI 53706 USA

来源：

SCIENCE | 2001年 / 292卷 / 5524期

关键词：

D O I：

10.1126/science.1059040

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The alpha subunit of a prototypical heterotrimeric GTP-binding protein (G protein), which is encoded by a single gene (GPA 1) in Arabidopsis, is a modulator of plant cell proliferation. gpa1 null mutants have reduced cell division in aerial tissues throughout development. Inducible overexpression of GPA1 in Arabidopsis confers inducible ectopic cell division. GPA1 overexpression in synchronized BY-2 cells causes premature advance of the nuclear cycle and the premature appearance of a division wall, Results from loss of function and ectopic expression and activation of GPA1 indicate that this subunit is a positive modulator of cell division in plants.

引用

页码：2066 / 2069

页数：4

共 28 条

[1] Rice gibberellin-insensitive dwarf mutant gene Dwarf 1 encodes the α-subunit of GTP-binding protein [J].