The extent of genetic diversity of Epstein-Barr virus and its geographic and disease patterns: A need for reappraisal

被引：176

作者：

Chang, Cindy M. ^{[1
]}

Yu, Kelly J. ^{[1
]}

Mbulaiteye, Sam M. ^{[1
]}

Hildesheim, Allan ^{[1
]}

Bhatia, Kishor ^{[1
]}

机构：

[1] NCI, Infect & Immunoepidemiol Branch, Div Canc Epidemiol & Genet, NIH, Rockville, MD 20892 USA

来源：

VIRUS RESEARCH | 2009年 / 143卷 / 02期

关键词：

EBV; Strain variation; Genetic diversity; Variants; Genotypes; EBNA1; BZLF1; LMP1; ZP; 30 bp deletion; Xhol loss; EBV types 1 and 2; B98-5; LATENT MEMBRANE PROTEIN-1; NUCLEAR ANTIGEN 1; UNDIFFERENTIATED NASOPHARYNGEAL CARCINOMA; CELL-IMMUNOCOMPROMISED INDIVIDUALS; PERIPHERAL-BLOOD LYMPHOCYTES; REACTIVE LYMPHOID-TISSUE; AIDS-RELATED LYMPHOMAS; AMINO-ACID CHANGES; SEQUENCE VARIATION; BURKITTS-LYMPHOMA;

D O I：

10.1016/j.virusres.2009.07.005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Epstein-Barr virus (EBV) is a ubiquitous, gamma-1 lymphotrophic virus etiologically linked to nasopharyngeal carcinoma (NPC) endemic to Southern China, and Burkitt lymphoma (BL), endemic to equatorial Africa, both of which are rare elsewhere in the world. Why EBV is associated with different malignancies in different geographic regions remains puzzling and may be related to EBV genotypic variability through specific disease and geographic associations. We review the literature on sequence variation in EBV genes, focusing on LMP-1, EBNA-1, and BZLF-1 and their distribution by geography and disease. Given the limitations of current studies, definitive conclusions regarding the link between EBV genotypes, disease and geography are not possible. We suggest that the true extent of EBV diversity is likely to be greater than is currently recognized. Additional studies conducted in carefully selected populations, that are sufficiently powered to provide robust estimates, and that utilize testing approaches that permit full characterization of viral diversity are needed to further our understanding of patterns of EBV genetic variation and their association with malignancies in different regions. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：209 / 221

页数：13

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