The extent of genetic diversity of Epstein-Barr virus and its geographic and disease patterns: A need for reappraisal

被引：176

作者：

Chang, Cindy M. ^{[1
]}

Yu, Kelly J. ^{[1
]}

Mbulaiteye, Sam M. ^{[1
]}

Hildesheim, Allan ^{[1
]}

Bhatia, Kishor ^{[1
]}

机构：

[1] NCI, Infect & Immunoepidemiol Branch, Div Canc Epidemiol & Genet, NIH, Rockville, MD 20892 USA

来源：

VIRUS RESEARCH | 2009年 / 143卷 / 02期

关键词：

EBV; Strain variation; Genetic diversity; Variants; Genotypes; EBNA1; BZLF1; LMP1; ZP; 30 bp deletion; Xhol loss; EBV types 1 and 2; B98-5; LATENT MEMBRANE PROTEIN-1; NUCLEAR ANTIGEN 1; UNDIFFERENTIATED NASOPHARYNGEAL CARCINOMA; CELL-IMMUNOCOMPROMISED INDIVIDUALS; PERIPHERAL-BLOOD LYMPHOCYTES; REACTIVE LYMPHOID-TISSUE; AIDS-RELATED LYMPHOMAS; AMINO-ACID CHANGES; SEQUENCE VARIATION; BURKITTS-LYMPHOMA;

D O I：

10.1016/j.virusres.2009.07.005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Epstein-Barr virus (EBV) is a ubiquitous, gamma-1 lymphotrophic virus etiologically linked to nasopharyngeal carcinoma (NPC) endemic to Southern China, and Burkitt lymphoma (BL), endemic to equatorial Africa, both of which are rare elsewhere in the world. Why EBV is associated with different malignancies in different geographic regions remains puzzling and may be related to EBV genotypic variability through specific disease and geographic associations. We review the literature on sequence variation in EBV genes, focusing on LMP-1, EBNA-1, and BZLF-1 and their distribution by geography and disease. Given the limitations of current studies, definitive conclusions regarding the link between EBV genotypes, disease and geography are not possible. We suggest that the true extent of EBV diversity is likely to be greater than is currently recognized. Additional studies conducted in carefully selected populations, that are sufficiently powered to provide robust estimates, and that utilize testing approaches that permit full characterization of viral diversity are needed to further our understanding of patterns of EBV genetic variation and their association with malignancies in different regions. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：209 / 221

页数：13

共 171 条

[1] EBV STRAIN VARIATION - GEOGRAPHICAL-DISTRIBUTION AND RELATION TO DISEASE STATE [J].

ABDELHAMID, M ;

CHEN, JJ ;

CONSTANTINE, N ;

MASSOUD, M ;

RAABTRAUB, N .

VIROLOGY, 1992, 190 (01) :168-175

[2] Characterization of intertypic recombinants of the Epstein-Barr virus from the body-cavity-based lymphomas cell lines BC-1 and BC-2 [J].

Aguirre, AJ ;

Robertson, ES .

VIROLOGY, 1999, 264 (02) :359-369

[3] HETEROGENEITY WITHIN THE EPSTEIN-BARR-VIRUS NUCLEAR ANTIGEN-2 GENE IN DIFFERENT STRAINS OF EPSTEIN-BARR-VIRUS [J].

AITKEN, C ;

SENGUPTA, SK ;

AEDES, C ;

MOSS, DJ ;

SCULLEY, TB .

JOURNAL OF GENERAL VIROLOGY, 1994, 75 :95-100

[4] The plasmid replicon of EBV consists of multiple cis-acting elements that facilitate DNA synthesis by the cell and a viral maintenance element [J].

Aiyar, A ;

Tyree, C ;

Sugden, B .

EMBO JOURNAL, 1998, 17 (21) :6394-6403

[5]

Al-Homsi AS, 1998, INT J MOL MED, V1, P983

[6]

[Anonymous], 2004, GLOBOCAN 2002 CANC I

[7] DETECTION OF A-TYPE AND B-TYPE EPSTEIN-BARR-VIRUS IN THROAT WASHINGS AND LYMPHOCYTES [J].

APOLLONI, A ;

SCULLEY, TB .

VIROLOGY, 1994, 202 (02) :978-981

[8] Polymorphism analysis of Epstein-Barr virus isolates of nasopharyngeal carcinoma biopsies from Tunisian patients [J].

Ayadi, Wajdi ;

Feki, Lamia ;

Khabir, Abdelmajid ;

Boudawara, Tahia ;

Ghorbel, Abdelmonem ;

Charfeddine, Ilhem ;

Daoud, Jamel ;

Frikha, Mounir ;

Hammami, Adnane ;

Karray-Hakim, Hela .

VIRUS GENES, 2007, 34 (02) :137-145

[9] DNA-SEQUENCE AND EXPRESSION OF THE B95-8 EPSTEIN-BARR VIRUS GENOME [J].

BAER, R ;

BANKIER, AT ;

BIGGIN, MD ;

DEININGER, PL ;

FARRELL, PJ ;

GIBSON, TJ ;

HATFULL, G ;

HUDSON, GS ;

SATCHWELL, SC ;

SEGUIN, C ;

TUFFNELL, PS ;

BARRELL, BG .

NATURE, 1984, 310 (5974) :207-211

[10] The oncogenic 30 and 69 bp deletion variants of the EBV LMP-1 gene are common in HIV-negative lymphoproliferations, both malignant and benign [J].

Barozzi, P ;

Luppi, M ;

Cagossi, K ;

Maiorana, A ;

Marasca, R ;

Artusi, T ;

Poggi, S ;

Pileri, SA ;

Torelli, G .

ANNALS OF ONCOLOGY, 1999, 10 (04) :467-469

← 1 2 3 4 5 6 7 8 9 10 →