Ligand-free iron-catalyzed benzylic C (sp3)-H amination of methylarenes with N-fluorobenzenesulfonimide

被引：13

作者：

Bao, Fengyu ^{[1
]}

Cao, Yuanbo ^{[1
]}

Liu, Wenbo ^{[1
]}

Zhu, Junhao ^{[1
]}

机构：

[1] Henan Agr Univ, Coll Sci, Zhengzhou 450002, Henan, Peoples R China

来源：

RSC ADVANCES | 2019年 / 9卷 / 48期

关键词：

H BOND AMINATION; METAL-ORGANIC FRAMEWORKS; INTERMOLECULAR AMIDATION; C(SP(3))-H BONDS; 8-METHYLQUINOLINES; FUNCTIONALIZATION; OXIDATION; DESIGN; DERIVATIVES; MECHANISM;

D O I：

10.1039/c9ra05294a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Direct conversion of cheap methylarenes to benzylic amines, which are essential structural units of important drugs, is of great significance. However, the known methodologies suffer from the requirement of noble metal catalysts, heavy metal residues or strong oxidants. Herein, the first biocompatible iron-catalyzed benzylic C (sp(3))-H amination of methylarenes with N-fluorobenzenesulfonimide is described. The reactions of methylarenes bearing electron-donating groups and electron-withdrawing groups ran smoothly under ligand and additional oxidant free conditions. Both toluene derivatives and 8-methylquinoline can be aminated by the same iron catalyst.

引用

页码：27892 / 27895

页数：4

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