Transplanted myogenic progenitor cells express neuronal markers in the CNS and ameliorate disease in Experimental Autoimmune Encephalomyelitis

被引：11

作者：

Aharoni, Rina ^{[1
]}

Aizman, Elizabeta ^{[1
]}

Fuchs, Ora

Arnon, Ruth ^{[1
]}

Yaffe, David

Sarig, Rachel

机构：

[1] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2009年 / 215卷 / 1-2期

关键词：

Myoblasts; Progenitor cells; Neurons; Multiple Sclerosis; Experimental Autoimmune Encephalomyelitis; Glatiramer acetate; MESENCHYMAL STEM-CELLS; NEUROTROPHIC FACTOR; MULTIPLE-SCLEROSIS; T-CELLS; BRAIN; DIFFERENTIATION; PRECURSORS; COPOLYMER; TRANSDIFFERENTIATION; NEUROGENESIS;

D O I：

10.1016/j.jneuroim.2009.08.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study explores the potential of non-neural progenitor cells for CNS cell therapy. Muscle progenitor cells (MPCs), transplanted either intraventricularly or intraperitonealy, incorporated into the CNS of EAE-induced but not of naive mice. Some of the migrating MPCs expressed the neuronal marker beta-III-Tubulin and gained neuronal morphology. Co-treatment of transplanted mice with the immunomodulatory agent glatiramer acetate (GA, Copaxone) resulted in improved MPCs incorporation and differentiation towards the neuronal pathway. The therapeutic potential of myogenic progenitor cells was demonstrated by amelioration of clinical symptoms and reduced mortality in EAE mice, as well as by expression of IL-10, TGF-beta, and the neurotrophin-BDNF. (C) 2009 Elsevier B.V. All rights reserved.

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页码：73 / 83

页数：11

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