GluR2-3Y Inhibits the Acquisition and Reinstatement of Morphine-Induced Conditioned Place Preference in Rats

被引：10
作者：
Lin, Xiao-Jing [1 ,2 ,4 ]
Zhang, Jian-Jun [1 ,2 ,3 ]
Yu, Long-Chuan [1 ,2 ]
机构：
[1] Peking Univ, Coll Life Sci, Neurobiol Lab, Beijing 100871, Peoples R China
[2] Peking Univ, Coll Life Sci, Natl Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China
[3] Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
[4] Natl Inst Biol Sci, Beijing 102206, Peoples R China
来源：
NEUROSCIENCE BULLETIN | 2016年 / 32卷 / 02期
基金：
中国国家自然科学基金;
关键词：
GluR2-3Y; AMPA receptors; Morphine; Conditioned place preference; Acquisition of mCPP; Reinstatement of mCPP; AMPA RECEPTOR ENDOCYTOSIS; VENTRAL TEGMENTAL AREA; LONG-TERM DEPRESSION; BEHAVIORAL SENSITIZATION; NUCLEUS-ACCUMBENS; PREFRONTAL CORTEX; EXPRESSION; EXTINCTION; ANTAGONIST; LY293558;
D O I：
10.1007/s12264-016-0018-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Accumulating evidence indicates that alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs) are involved in the relapse to abused drugs. However, the role of AMPARs containing the GluR2 subunit in opiate addiction is still unclear. GluR2-3Y, an interfering peptide, prevents the endocytosis of AMPARs containing the GluR2 subunit. In this study, we explored the effect of intravenous injection of GluR2-3Y on the acquisition, expression, and reinstatement of morphine-induced conditioned place preference (mCPP) in rats. We found that infusion of GluR2-3Y (1.5 nmol/g) one hour before morphine during the conditioning phase inhibited the acquisition of mCPP, while an identical injection one hour before the post-conditioning test had no influence on the expression of mCPP. Injection of GluR2-3Y (1.5 nmol/g) after mCPP extinction blocked the morphine-induced reinstatement of mCPP. Our results strongly support the hypothesis that inhibition of AMPAR endocytosis provides a new target for the treatment of opiate addiction.
引用
收藏
页码：177 / 182
页数：6
相关论文
共 29 条
[1]   Tyrosine phosphorylation of GluR2 is required for insulin-stimulated AMPA receptor endocytosis and LTD [J].
Ahmadian, G ;
Ju, W ;
Liu, LD ;
Wyszynski, M ;
Lee, SH ;
Dunah, AW ;
Taghibiglou, C ;
Wang, YS ;
Lu, J ;
Wong, TP ;
Sheng, M ;
Wang, YT .
EMBO JOURNAL, 2004, 23 (05) :1040-1050
[2]   Cocaine triggered AMPA receptor redistribution is reversed in vivo by mGluR-dependent long-term depression [J].
Bellone, C ;
Lüscher, C .
NATURE NEUROSCIENCE, 2006, 9 (05) :636-641
[3]   Increased Insertion of Glutamate Receptor 2-Lacking α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid (AMPA) Receptors at Hippocampal Synapses upon Repeated Morphine Administration [J].
Billa, Sophie K. ;
Liu, Jie ;
Bjorklund, Nicole L. ;
Sinha, Namita ;
Fu, Yu ;
Shinnick-Gallagher, Patricia ;
Moron, Jose A. .
MOLECULAR PHARMACOLOGY, 2010, 77 (05) :874-883
[4]   Nucleus accumbens long-term depression and the expression of behavioral sensitization [J].
Brebner, K ;
Wong, TP ;
Liu, LD ;
Liu, YT ;
Campsall, P ;
Gray, S ;
Phelps, L ;
Phillips, AG ;
Wang, YT .
SCIENCE, 2005, 310 (5752) :1340-1343
[5]  
Carlezon WA, 1999, SYNAPSE, V31, P256, DOI 10.1002/(SICI)1098-2396(19990315)31:4<256::AID-SYN3>3.0.CO
[6]  
2-E
[7]   Facilitated extinction of morphine conditioned place preference with Tat-GluA23y interference peptide [J].
Dias, C. ;
Wang, Y. T. ;
Phillips, A. G. .
BEHAVIOURAL BRAIN RESEARCH, 2012, 233 (02) :389-397
[8]   Combined action of MK-801 and ceftriaxone impairs the acquisition and reinstatement of morphine-induced conditioned place preference, and delays morphine extinction in rats [J].
Fan, Yaodong ;
Niu, Haichen ;
Rizak, Joshua D. ;
Li, Ling ;
Wang, Guimei ;
Xu, Liqi ;
Ren, He ;
Lei, Hao ;
Yu, Hualin .
NEUROSCIENCE BULLETIN, 2012, 28 (05) :567-576
[9]   Influence of cholinesterase inhibitors, donepezil and rivastigmine on the acquisition, expression, and reinstatement of morphine-induced conditioned place preference in rats [J].
Gawel, Kinga ;
Labuz, Krzysztof ;
Jenda, Malgorzata ;
Silberring, Jerzy ;
Kotlinska, Jolanta H. .
BEHAVIOURAL BRAIN RESEARCH, 2014, 268 :169-176
[10]   Chronic administration of morphine is associated with a decrease in surface AMPA GluR1 receptor subunit in dopamine D1 receptor expressing neurons in the shell and non-D1 receptor expressing neurons in the core of the rat nucleus accumbens [J].
Glass, Michael J. ;
Lane, Diane A. ;
Colago, Eric E. O. ;
Chan, June ;
Schlussman, Stefan D. ;
Zhou, Yan ;
Kreek, Mary Jeanne ;
Pickel, Virginia M. .
EXPERIMENTAL NEUROLOGY, 2008, 210 (02) :750-761
123