Friedel-Crafts-type alkylation in aqueous media using resin-supported peptide catalyst having polyleucine

被引：36

作者：

Akagawa, Kengo ^{[1
]}

Yamashita, Takuhiro ^{[1
]}

Sakamoto, Seiji ^{[2
]}

Kudo, Kazuaki ^{[1
]}

机构：

[1] Univ Tokyo, Inst Ind Sci, Meguro Ku, Tokyo 1538505, Japan

[2] Tohoku Univ, Inst Multidisciplinary Res Adv Mat, Aoba Ku, Sendai, Miyagi 9808577, Japan

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 40期

关键词：

ASYMMETRIC TRANSFER HYDROGENATION; CYCLIC 1,3-DICARBONYL COMPOUNDS; INDOLE ALKYLATIONS; CONSTRUCTION; ORGANOCATALYSTS; NITROALKENES; PYRROLE; ALKENES; SILICA;

D O I：

10.1016/j.tetlet.2009.07.071

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric Friedel-Crafts-type alkylation in aqueous media was realized by the resin-supported N-terminal prolyl peptide catalyst having a polyleucine tether. The hydrophobic polyleucine chain in the peptide catalyst was essential for the reaction efficiency and enantioselectivity. The resin-bound peptide catalyst could be reused at least for five times. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：5602 / 5604

页数：3

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