Microwave Enabled Umpulong Mechanism Based Rapid and Efficient Four- and Six-Component Domino Formations of 2-(2′-Azaaryl)imidazoles and anti-1,2-Diarylethylbenzamides

被引：64

作者：

Jiang, Bo ^{[1
,2
]}

Wang, Xiang ^{[1
]}

Shi, Feng ^{[1
]}

Tu, Shu-Jiang ^{[1
,2
]}

Ai, Teng ^{[3
]}

Ballew, Austin ^{[3
]}

Li, Guigen ^{[3
]}

机构：

[1] Xuzhou Normal Univ, Sch Chem & Chem Engn, Xuzhou 221116, Jiangsu, Peoples R China

[2] Suzhou Univ, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Jiangsu, Peoples R China

[3] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 24期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

N-HETEROCYCLIC CARBENES; 3-COMPONENT SYNTHESIS; 2-(2-PYRIDYL)IMIDAZOLE; BENZALDEHYDE; DERIVATIVES; COMPLEXES; CATALYST; ANION;

D O I：

10.1021/jo902204s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Concise and efficient six-component and four-component domino approaches to anti-1,2-diarylethylbenzamides and highly Substituted 2-(2'-azaaryl)imidazoles have been developed under solvent-free and microwave-irradiation conditions. The reactions showed a broad scope of substrates in which a wide range of common commercial aromatic aldehydes and heteroaryl nitriles can be used. The syntheses were Finished within short periods (15-34 min) with good to excellent chemical yields and stereoselectivity that avoided tedious workup isolations. New mechanisms involving an umpolung have been proposed for these two reaction processes.

引用

页码：9486 / 9489

页数：4

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