The Third International Consensus Guidelines on the Management of Cytomegalovirus in Solid-organ Transplantation

被引：884

作者：

Kotton, Camille N. ^{[1
]}

Kumar, Deepali ^{[2
]}

Caliendo, Angela M. ^{[3
]}

Huprikar, Shirish ^{[4
]}

Chou, Sunwen ^{[5
]}

Danziger-Isakov, Lara ^{[6
]}

Humar, Atul ^{[7
]}

机构：

[1] Harvard Med Sch, Massachusetts Gen Hosp, Transplant & Immunocompromised Host Infect Dis In, 55 Fruit St,Cox 5, Boston, MA 02114 USA

[2] Univ Hlth Network, Transplant Infect Dis & Multiorgan Transplant Pro, Toronto, ON, Canada

[3] Rhode Isl Hosp, Providence, RI USA

[4] Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA

[5] Oregon Hlth & Sci Univ, Div Infect Dis, Portland, OR 97201 USA

[6] Cincinnati Childrens Hosp Med Ctr, Div Infect Dis, Cincinnati, OH 45229 USA

[7] Univ Hlth Network, Multi Organ Transplant Program, Toronto, ON, Canada

来源：

TRANSPLANTATION | 2018年 / 102卷 / 06期

关键词：

CELL-MEDIATED-IMMUNITY; DRUG-RESISTANT CYTOMEGALOVIRUS; INTRAVENOUS IMMUNOGLOBULIN REPLACEMENT; BRONCHOALVEOLAR LAVAGE FLUID; MANNOSE-BINDING LECTIN; EPSTEIN-BARR-VIRUS; DELTA T-CELLS; EXTENDED VALGANCICLOVIR PROPHYLAXIS; BRONCHIOLITIS OBLITERANS SYNDROME; PEDIATRIC RENAL-TRANSPLANTATION;

D O I：

10.1097/TP.0000000000002191

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Despite recent advances, cytomegalovirus (CMV) infections remain one of the most common complications affecting solid organ transplant recipients, conveying higher risks of complications, graft loss, morbidity, and mortality. Research in the field and development of prior consensus guidelines supported by The Transplantation Society has allowed a more standardized approach to CMV management. An international multidisciplinary panel of experts was convened to expand and revise evidence and expert opinion-based consensus guidelines on CMV management including prevention, treatment, diagnostics, immunology, drug resistance, and pediatric issues. Highlights include advances in molecular and immunologic diagnostics, improved understanding of diagnostic thresholds, optimized methods of prevention, advances in the use of novel antiviral therapies and certain immunosuppressive agents, and more savvy approaches to treatment resistant/refractory disease. The following report summarizes the updated recommendations.

引用

页码：900 / 931

页数：32

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