Role of viral isolate in the etiopathogenetic determinism of HCV infection: Diagnostic and epidemiological evaluation

被引：0

作者：

Ravera, G ^{[1
]}

Franceschini, M ^{[1
]}

Zanardi, S ^{[1
]}

Bottaro, LC ^{[1
]}

Colombi, T ^{[1
]}

Percario, GF ^{[1
]}

Carbone, M ^{[1
]}

机构：

[1] Univ Genoa, ASL Genovese Clin Pathol Dept 3, I-16126 Genoa, Italy

来源：

MICROBIOLOGICA | 2001年 / 24卷 / 04期

关键词：

HCV; viral isolate;

D O I：

暂无

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

HCV genotyping by nucleic acid sequencing emphasizes the difficulties involved in carrying out a more precise determination of the infectant viral population, probably due in part to the finding of still unknown isolates. Signs of heterogeneity in the genotype composition of the viral quasi-species and its evolutionary dynamism over time, together with the role played by some, more potentially aggressive, isolates in causing hepatic damage, encourage a more in-depth study of such topics.

引用

页码：317 / 324

页数：8

共 22 条

[1] AT LEAST 12 GENOTYPES OF HEPATITIS-C VIRUS PREDICTED BY SEQUENCE-ANALYSIS OF THE PUTATIVE E1-GENE OF ISOLATES COLLECTED WORLDWIDE
BUKH, J
PURCELL, RH
MILLER, RH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) : 8234 - 8238
[2] CARBONE M, 1997, PANDORA, V1, P21
[3] AT LEAST 5 RELATED, BUT DISTINCT, HEPATITIS-C VIRAL GENOTYPES EXIST
CHA, TA
BEALL, E
IRVINE, B
KOLBERG, J
CHIEN, D
KUO, G
URDEA, MS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (15) : 7144 - 7148
[4] FRANCESCHINI M, 1998, MICROBIOLOGIA MED, V13, P34
[5] FRANCESCHINI M, 1993, 12 S EP AIDS RIM IT, P76
[6] FRANCESCHINI M, 1998, MICROBIOLOGIA MED, V13, P626
[7] FRANCESCHINI M, 1997, CLIN LIGAND ASSAY, V20, P219
[8] Genetic heterogeneity of hepatitis C virus and its clinical implications
Marousis, CG
Lau, JYN
[J]. DIGESTIVE DISEASES, 1997, 15 (4-5) : 192 - 206
[9] Molecular evolution of hepatitis viruses
Mizokami, M
Orito, E
[J]. INTERVIROLOGY, 1999, 42 (2-3) : 159 - 165
[10] Differences in viral dynamics between genotypes 1 and 2 of hepatitis C virus
Neumann, AU
Lam, NP
Dahari, H
Davidian, M
Wiley, TE
Mika, BP
Perelson, AS
Layden, TJ
[J]. JOURNAL OF INFECTIOUS DISEASES, 2000, 182 (01) : 28 - 35

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