The pregnancy hormone relaxin is a player in human heart failure

被引：175
作者：
Dschietzig, T
Richter, C
Bartsch, C
Laule, M
Armbruster, FP
Baumann, G
Stangl, K
机构：
[1] Charite, Med Klin & Poliklin S Kardiol Angiol Pulmol, D-10098 Berlin, Germany
[2] Immundiagnost AG, D-64625 Bensheim, Germany
来源：
FASEB JOURNAL | 2001年 / 15卷 / 12期
关键词：
RLX; congestive; endothelin; 1; angiotensin II; gene expression;
D O I：
10.1096/fj.01-0070com
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Human congestive heart failure is characterized by complex neurohumoral activation associated with the up-regulation of vasoconstricting and salt-retaining mediators and the compensatory rise of counter-regulatory hormones. In the present study, we provide the first evidence that relaxin (RLX), known as a pregnancy hormone, represents a potential compensatory mediator in human heart failure: plasma concentrations of RLX and myocardial expression of the two RLX genes (H1 and H2) correlate with the severity of disease and RLX responds to therapy. The failing human heart is a relevant source of circulating RLX peptides, and myocytes as well as interstitial cells produce RLX. Elevation of ventricular filling pressure up-regulates RLX expression and the hormone acts as a potent inhibitor of endothelin 1, the most powerful vasoconstrictor in heart failure. Furthermore, RLX modulates effects of angiotensin II, another crucial mediator. Our data identify RLX as a new player in human heart failure with potential diagnostic and therapeutic relevance.
引用
收藏
页码：2187 / 2195
页数：9
相关论文
共 26 条
[11]   Expression of human relaxin genes: Characterization of a novel alternatively-spliced human relaxin mRNA species [J].
Gunnersen, JM ;
Fu, P ;
Roche, PJ ;
Tregear, GW .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1996, 118 (1-2) :85-94
[12]  
HAMOLSKY M, 1945, P SOC EXP BIOL MED, V60, P8, DOI 10.3181/00379727-60-15074P
[13]  
HISAW F, 1926, P SOC EXP BIOL MED, V23, P899
[14]  
HOLM S, 1979, SCAND J STAT, V6, P65
[15]   RELAXIN GENE-EXPRESSION IN HUMAN OVARIES AND THE PREDICTED STRUCTURE OF A HUMAN PREPRORELAXIN BY ANALYSIS OF CDNA CLONES [J].
HUDSON, P ;
JOHN, M ;
CRAWFORD, R ;
HARALAMBIDIS, J ;
SCANLON, D ;
GORMAN, J ;
TREGEAR, G ;
SHINE, J ;
NIALL, H .
EMBO JOURNAL, 1984, 3 (10) :2333-2339
[16]   STRUCTURE OF A GENOMIC CLONE ENCODING BIOLOGICALLY-ACTIVE HUMAN RELAXIN [J].
HUDSON, P ;
HALEY, J ;
JOHN, M ;
CRONK, M ;
CRAWFORD, R ;
HARALAMBIDIS, J ;
TREGEAR, G ;
SHINE, J ;
NIALL, H .
NATURE, 1983, 301 (5901) :628-631
[17]   MOLECULAR-CLONING AND CHARACTERIZATION OF CDNA SEQUENCES CODING FOR RAT RELAXIN [J].
HUDSON, P ;
HALEY, J ;
CRONK, M ;
SHINE, J ;
NIALL, H .
NATURE, 1981, 291 (5811) :127-131
[18]  
Lippert T. H., 1996, Clinical and Experimental Obstetrics and Gynecology, V23, P65
[19]   PROHORMONE CONVERTASE-1 WILL PROCESS PRORELAXIN, A MEMBER OF THE INSULIN FAMILY OF HORMONES [J].
MARRIOTT, D ;
GILLECECASTRO, B ;
GORMAN, CM .
MOLECULAR ENDOCRINOLOGY, 1992, 6 (09) :1441-1450
[20]   Interactions between endothelin-1 and the renin- angiotensin-aldosterone system [J].
Rossi, GP ;
Sacchetto, A ;
Cesari, M ;
Pessina, AC .
CARDIOVASCULAR RESEARCH, 1999, 43 (02) :300-307
123