Microgel-reinforced PVA hydrogel with self-healing and hyaluronic acid drug-releasing properties

被引：7

作者：

Chang, Yi-An ^{[1
]}

Chou, Ying-Nien ^{[1
]}

Lin, Yiu-Jiuan ^{[2
]}

Chen, Wei-Yu ^{[1
]}

Chen, Chuh-Yean ^{[1
]}

Lin, Hong-Ru ^{[1
]}

机构：

[1] Southern Taiwan Univ Sci & Technol, Dept Chem & Mat Engn, Tainan 71005, Taiwan

[2] Chung Hwa Univ Med Technol, Dept Nursing, Tainan, Taiwan

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2021年 / 70卷 / 17期

关键词：

Drug release; macro-cross-linker; microgel; PVA hydrogel; self-healing; HIGH MECHANICAL STRENGTH; CHEMISTRY; NETWORK; FABRICATION;

D O I：

10.1080/00914037.2020.1785460

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

A beneficial mircogel-reinforced polyvinyl alcohol (PVA) hydrogel is presented, aiming at improving its mechanical strength, self-healing, and drug-releasing features. The guar gum based microgel was prepared by inverse emulsion polymerization and cross-reacted with PVA and borax to form a network structure. The macro cross-linker and the PVA polymer chain were strongly bonded to generate a self-healable microgel-reinforced PVA hydrogel. The hydrogel was incorporated with hyaluronic acid and simulated its drug-releasing behavior. This work suggests that the microgel reinforced of macro-crosslinking PVA networks gives them a great potential in the design of self-healing and drug-releasing hydrogels.

引用

页码：1224 / 1235

页数：12

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