Pseudogene repair driven by selection pressure applied in experimental evolution

被引：19

作者：

Anand, Amitesh ^{[1
]}

Olson, Connor A. ^{[1
]}

Yang, Laurence ^{[1
]}

Sastry, Anand V. ^{[1
]}

Catoiu, Edward ^{[1
]}

Choudhary, Kumari Sonal ^{[1
]}

Phaneuf, Patrick V. ^{[1
]}

Sandberg, Troy E. ^{[1
]}

Xu, Sibei ^{[1
]}

Hefner, Ying ^{[1
]}

Szubin, Richard ^{[1
]}

Feist, Adam M. ^{[1
,2
]}

Palsson, Bernhard O. ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

[2] Tech Univ Denmark, Novo Nordisk Fdn Ctr Biosustainabil, Lyngby, Denmark

来源：

NATURE MICROBIOLOGY | 2019年 / 4卷 / 03期

关键词：

ESCHERICHIA-COLI; BACTERIAL; TRANSPORTER; GENES;

D O I：

10.1038/s41564-018-0340-2

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Pseudogenes represent open reading frames that have been damaged by mutations, rendering the gene product nonfunctional. Pseudogenes are found in many genomes and are not always eliminated, even if they are potentially 'wasteful'. This raises a fundamental question about their prevalence. Here we report pseudogene efeU repair that restores the iron uptake system of Escherichia coli under a designed selection pressure during adaptive laboratory evolution.

引用

页码：386 / 389

页数：4

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