Anti HIV-1 activity, anti bacterial activity and phytochemical analysis of leaf extracts from Cleistanthus collinus (Roxb.) Benth. ex Hook.f.

被引：0

作者：

Mohanraj, Remya ^{[1
]}

Haidar, Shoaib ^{[1
]}

Nobre, Malcolm ^{[1
]}

Anantan, R. ^{[2
]}

机构：

[1] MGM Inst Hlth Sci, Dept Med Biotechnol, Sect 18, Navi Mumbai 410209, Maharashtra, India

[2] Natl Inst Nutr, Food Chem Div, Hyderabad 500007, Andhra Pradesh, India

来源：

INDIAN JOURNAL OF TRADITIONAL KNOWLEDGE | 2018年 / 17卷 / 04期

关键词：

Cleistanthus collinus; Anti-; HIV; 1; p24 antigen expression; HPLC; Antibacterial activity; Phytochemicals; Lymphocyte culture; REVERSE-TRANSCRIPTASE; MEDICINAL-PLANTS; ANTIOXIDANT;

D O I：

暂无

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

This study is an attempt to identify new chemical entities with anti HIV1 activity. In vitro anti-HIV activity of Cleistanthus collinus extracts was evaluated using the p24 antigen assay. A dose-dependent inhibition of the p24 antigen expression was observed and the extract was found to be efficient against HIV-1. Antibacterial activity was tested against four different bacteria employing the agar well diffusion method and the highest activity was exhibited by the chloroform and methanolic extracts of C. collinus. HPLC analysis of the crude extract revealed the presence of phytochemicals like Gallic acid, Chlorogenic acid, 3,4 Dihydroxy B-acid, Diadizin, p-Coumaric acid, Epi-GC Gallate, Ellagic acid, Luteoline, Hesperitin and Quercetin. This report on the anti HIV 1 activity of C. collinus and the results obtained from the present study suggest that the extracts could serve as a source for providing potential lead compound for drug discovery against HIV-1.

引用

页码：770 / 775

页数：6

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