A new steroidal saponin with antiinflammatory and antiulcerogenic properties from the bulbs of Allium ampeloprasum var. porrum

被引：35
|
作者：
Adao, Camila Rodrigues [1 ]
da Silva, Bernadete Pereira [1 ]
Parente, Jose Paz [1 ]
机构：
[1] Univ Fed Rio de Janeiro, Lab Quim Plantas Med, Nucleo Pesquisas Prod Nat, Ctr Ciencias Saude, BR-21941971 Rio De Janeiro, Brazil
来源：
FITOTERAPIA | 2011年 / 82卷 / 08期
关键词：
Allium ampeloprasum var. porrum; Liliaceae; Steroidal saponins; Anti inflammatory; Antiulcerogenic; HEMOLYTIC ACTIVITIES; ASPARAGUS-RACEMOSUS; SMILAX-CHINA; MONOSACCHARIDES; LESIONS;
D O I：
10.1016/j.fitote.2011.08.003
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new steroidal saponin was isolated from the bulbs of Allium ampeloprasum var. porrum L On the basis of chemical evidence, comprehensive spectroscopic analyses and comparison of known compounds, its structure was established as (3 beta,5 alpha,6 beta,25R)-6-[(beta-D-glucopyranosyl)oxy]spirostan-3-yl O-beta-D-glucopyranosyl-(1 -> 2)-O-[beta-D-glucopyranosyl-(1 -> 3)]-beta-D-galactopyranoside (1). Results of the present study indicated that the steroidal saponin showed haemolytic effects in the in vitro assays and demonstrated antiinflammatory activity and gastroprotective property using in vivo models. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：1175 / 1180
页数：6
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