Interaction of LNA oligonucleotides with MDR1 promoter

被引：7

作者：

Chernolovskaya, EL

Koshkin, AA

Vlassov, VV

机构：

[1] Novosibirsk Bioorgan Chem Inst, Novosibirsk 630090, Russia

[2] Exiqon AS, DK-2950 Vedbaek, Denmark

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2001年 / 20卷 / 4-7期

关键词：

D O I：

10.1081/NCN-100002443

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

LNA oligonucleotides [1] can be used for targetting to double stranded DNA by the "strand invasion" mechanism. We used affinity modification by reactive oligonucleotide conjugates for investigation of oligonucleotides interaction with structured DNA. The tested LNAs and oligonucleotides of the same sequence were assayed as anti-mdr1 drugs in different cell cultures. One of the oligos, LNA79 strongly inhibited mdr1 induction in Hela cells and totally prevented activation of indr1 in K-562.

引用

页码：847 / 850

页数：4

共 2 条

[1] INDUCTION OF MULTIDRUG RESISTANCE IN HUMAN-CELLS BY TRANSIENT EXPOSURE TO DIFFERENT CHEMOTHERAPEUTIC DRUGS [J].