Effects of Different Medical Treatments on Serum Copper, Selenium and Zinc Levels in Patients with Rheumatoid Arthritis

被引：45

作者：

Onal, Suleyman ^{[1
]}

Naziroglu, Mustafa ^{[2
]}

Colak, Mesut ^{[3
]}

Bulut, Vedat ^{[4
]}

Flores-Arce, Manuel F. ^{[5
]}

机构：

[1] Isparta State Hosp, Dept Clin Microbiol, Isparta, Turkey

[2] Suleyman Demirel Univ, Fac Med, Dept Biophys, TR-32200 Isparta, Turkey

[3] Firat Univ, Fac Med, Dept Internal Med, TR-23169 Elazig, Turkey

[4] Gazi Univ, Fac Med, Dept Clin Microbiol, Ankara, Turkey

[5] Tijuana Inst Technol, Dept Chem & Biochem Engn, Tijuana, Mexico

来源：

BIOLOGICAL TRACE ELEMENT RESEARCH | 2011年 / 142卷 / 03期

关键词：

Rheumatoid arthritis; Selenium; Zinc; Copper; Inflammation; Methotrexate; OXIDATIVE STRESS; PLASMA SELENIUM; METHOTREXATE;

D O I：

10.1007/s12011-010-8826-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of the present study was to measure the changes in serum selenium, zinc, and copper in patients being treated for rheumatoid arthritis. Thirty-two patients and 52 healthy controls were included in the study. The copper level was higher and those of selenium and zinc were lower in the patients relative to controls. Treatment with methotrexate elevated the zinc levels, but not zinc and selenium. Treatments with salazopyrin, corticosteroids, chloroquine, and non-steroidal anti-inflammatory drugs did not change the levels of any of the elements studied. The decrease in zinc and selenium levels and elevation in copper levels observed in the patients probably resulted from the defense response of organism and are mediated by inflammatory-like substances.

引用

页码：447 / 455

页数：9

共 25 条

[1] Effect of methotrexate administration on status of some essential trace elements and antioxidant enzymes in pregnant rats in late gestation [J].

Al-Saleh, E. ;

Al-Harmi, J. ;

Nandakumaran, M. ;

Al-Shammari, M. ;

Al-Jassar, W. .

GYNECOLOGICAL ENDOCRINOLOGY, 2009, 25 (12) :816-822

[2]

Ala S, 2009, Pak J Biol Sci, V12, P1041

[3] Copper and zinc intake and serum levels in patients with juvenile rheumatoid arthritis [J].

Amancio, OMS ;

Chaud, DMA ;

Yanaguibashi, G ;

Hilário, MOE .

EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2003, 57 (05) :706-712

[4] Caffeic acid phenethyl ester modulates methotrexate-induced oxidative stress in testes of rat [J].

Armagan, A. ;

Uzar, E. ;

Uz, E. ;

Yilmaz, H. R. ;

Kutluhan, S. ;

Koyuncuoglu, H. R. ;

Soyupek, S. ;

Cam, H. ;

Serel, T. A. .

HUMAN & EXPERIMENTAL TOXICOLOGY, 2008, 27 (07) :547-552

[5] THE AMERICAN-RHEUMATISM-ASSOCIATION 1987 REVISED CRITERIA FOR THE CLASSIFICATION OF RHEUMATOID-ARTHRITIS [J].

ARNETT, FC ;

EDWORTHY, SM ;

BLOCH, DA ;

MCSHANE, DJ ;

FRIES, JF ;

COOPER, NS ;

HEALEY, LA ;

KAPLAN, SR ;

LIANG, MH ;

LUTHRA, HS ;

MEDSGER, TA ;

MITCHELL, DM ;

NEUSTADT, DH ;

PINALS, RS ;

SCHALLER, JG ;

SHARP, JT ;

WILDER, RL ;

HUNDER, GG .

ARTHRITIS AND RHEUMATISM, 1988, 31 (03) :315-324

[6] Role of nitric oxide and reactive oxygen species in arthritis [J].

Cuzzocrea, Salvatore .

CURRENT PHARMACEUTICAL DESIGN, 2006, 12 (27) :3551-3570

[7]

DIXON JS, 1985, INT J CLIN PHARM RES, V5, P25

[8] THE ROLE OF ZINC IN REPRODUCTION - HORMONAL MECHANISMS [J].

FAVIER, AE .

BIOLOGICAL TRACE ELEMENT RESEARCH, 1992, 32 :363-382

[9]

Helgeland M, 2000, CLIN EXP RHEUMATOL, V18, P637

[10] Plasma lipid peroxidation and antioxidant levels in patients with rheumatoid arthritis [J].

Kamanli, A ;

Naziroglu, M ;

Aydilek, N ;

Hacievhyagil, C .

CELL BIOCHEMISTRY AND FUNCTION, 2004, 22 (01) :53-57

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