A database of immunoglobulins with integrated tools: DIGIT

被引:30
作者
Chailyan, Anna [1 ]
Tramontano, Anna [1 ,2 ]
Marcatili, Paolo [1 ]
机构
[1] Univ Roma La Sapienza, Dept Phys, I-00185 Rome, Italy
[2] Ist Italiano Tecnol, Ctr Life Nano Sci, I-00161 Rome I, Italy
关键词
HYPERVARIABLE REGION; CANONICAL STRUCTURES; CONFORMATIONS; PREDICTION;
D O I
10.1093/nar/gkr806
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The DIGIT (Database of ImmunoGlobulins with Integrated Tools) database (http://biocomputing.it/digit) is an integrated resource storing sequences of annotated immunoglobulin variable domains and enriched with tools for searching and analyzing them. The annotations in the database include information on the type of antigen, the respective germline sequences and on pairing information between light and heavy chains. Other annotations, such as the identification of the complementarity determining regions, assignment of their structural class and identification of mutations with respect to the germline, are computed on the fly and can also be obtained for user-submitted sequences. The system allows customized BLAST searches and automatic building of 3D models of the domains to be performed.
引用
收藏
页码:D1230 / D1234
页数:5
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