Targeting neurotrophin-3 and its dependence receptor tyrosine kinase receptor C: a new antitumoral strategy

被引：14

作者：

Tauszig-Delamasure, Servane ^{[1
]}

Bouzas-Rodriguez, Jimena ^{[1
]}

机构：

[1] Univ Lyon, Ctr Leon Berard, CNRS,Ctr Cancerol Lyon,INSERM,U1052,UMR5238, Apoptosis Canc & Dev Lab,Equipe Labellisee La Lig, F-69008 Lyon, France

来源：

EXPERT OPINION ON THERAPEUTIC TARGETS | 2011年 / 15卷 / 07期

关键词：

apoptosis; dependence receptor; neuroblastoma; neurotrophin; NT-3; TrkC; NERVE GROWTH-FACTOR; PHASE-I TRIAL; CASPASE CLEAVAGE; HUMAN NEUROBLASTOMAS; MESSENGER-RNAS; HUMAN MEDULLOBLASTOMA; SURVIVAL FACTOR; CELL INVASION; NETRIN-1; ACTS; FACTOR FAMILY;

D O I：

10.1517/14728222.2011.575361

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Areas covered: The role of neurotrophin-3 (NT-3) and its dependence receptor TrkC in neuroblastoma, and its suitability as a therapeutic target. Expert opinion: Autocrine production of NT-3 represents a selective advantage for tumor growth and dissemination, in a large fraction of aggressive neuroblastoma. Disruption of the NT-3 autocrine loop in malignant neuroblasts, triggers neuroblastoma cell death, and inhibits neuroblastoma metastasis in animal models. Thus, a novel way of targeting the tyrosine kinase receptor, is via the reactivation of its intrinsic ability to trigger cell death.

引用

页码：847 / 858

页数：12

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