The association between body composition and cystatin C in South Asians: Results from the MASALA study

被引：4
作者：
Shah, Arti D. [1 ]
Schmidt, Heidi [2 ]
Sen, Saunak [3 ]
Shlipak, Michael G. [3 ,4 ]
Kanaya, Alka M. [2 ,3 ]
机构：
[1] Univ Calif San Francisco, Div Endocrinol & Metab, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Med, Div Gen Internal Med, San Francisco, CA USA
[3] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA
[4] San Francisco VA Med Ctr, Div Gen Internal Med, San Francisco, CA USA
来源：
OBESITY RESEARCH & CLINICAL PRACTICE | 2015年 / 9卷 / 02期
关键词：
Body composition; Ectopic fat; Cystatin C; South Asian; CHRONIC KIDNEY-DISEASE; GLOMERULAR-FILTRATION-RATE; ADIPOSE-TISSUE; SUBCUTANEOUS ADIPOSITY; ATHEROSCLEROSIS; AMERICA; COHORT;
D O I：
10.1016/j.orcp.2014.10.221
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
While South Asians have high rates of obesity and kidney disease, little is known about the effect of regional body composition on kidney function. We investigated the association between body composition measures and cystatin C-based estimated glomerular filtration rate (eGFR(cysC)) in 150 immigrant South Asians. The inverse association between overall adiposity and eGFR(cysC) was attenuated by C-reactive protein (CRP), while the association of ectopic fat was completely attenuated by metabolic covariates and CRP. In immigrant South Asians, the associations between overall adiposity and ectopic fat with decreased kidney function are largely explained by metabolic alterations and inflammation. (C) 2014 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：180 / 183
页数：4
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