CD36 favours fat sensing and transport to govern lipid metabolism

被引：88
作者：
Li, Yunxia [1 ]
Huang, Xingguo [1 ]
Yang, Guan [2 ]
Xu, Kang [3 ]
Yin, Yulong [1 ]
Brecchia, Gabriele [4 ]
Yin, Jie [1 ]
机构：
[1] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Peoples R China
[2] City Univ Hong Kong, Dept Infect Dis & Publ Hlth, Hong Kong, Peoples R China
[3] Chinese Acad Sci, Inst Subtrop Agr, Changsha 410125, Peoples R China
[4] Univ Milan, Dept Vet Med, Via Univ, I-26900 Lodi, Italy
来源：
PROGRESS IN LIPID RESEARCH | 2022年 / 88卷
基金：
中国国家自然科学基金;
关键词：
CD36; Fatty acids; Lipid transport; Lipid sensing; Lipid dysmetabolism; Obesity; SINGLE-NUCLEOTIDE POLYMORPHISM; ACID UPTAKE; CHOLESTEROL UPTAKE; GUT MICROBIOTA; ADIPOSE-TISSUE; GENE VARIANTS; LIVER-DISEASE; OXLDL UPTAKE; PPAR-GAMMA; OBESITY;
D O I：
10.1016/j.plipres.2022.101193
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
CD36, located on the cell membrane, transports fatty acids in response to dietary fat. It is a critical fatty acid sensor and regulator of lipid metabolism. The interaction between CD36 and lipid dysmetabolism and obesity has been identified in various models and human studies. Nevertheless, the mechanisms by which CD36 regulates lipid metabolism and the role of CD36 in metabolic diseases remain obscure. Here, we summarize the latest research on the role of membrane CD36 in fat metabolism, with emphasis on CD36-mediated fat sensing and transport. This review also critically discusses the factors affecting the regulation of CD36-mediated fat dysfunction. Finally, we review previous clinical evidence of CD36 in metabolic diseases and consider the path forward.
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页数：10
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