MOG-antibody-associated hypertrophic pachymeningitis

被引：7
作者：
Papathanasiou, Athanasios [1 ]
Yeo, Jing-Ming [1 ]
Humberstone, Miles [2 ]
Hosseini, Akram A. [1 ]
机构：
[1] Nottingham Univ Hosp NHS Trust, Queens Med Ctr, Dept Neurol, Nottingham NG7 2UH, England
[2] United Lincolnshire Hosp NHS Trust, Dept Neurol, Queens Med Ctr, Nottingham, England
来源：
MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2020年 / 42卷
基金：
英国医学研究理事会;
关键词：
MOG; Myelin oligodendrocyte glycoprotein; Seizure; Cognition; Hypertrophic pachymeningitis; DISEASE;
D O I：
10.1016/j.msard.2020.102074
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: The clinical spectrum of myelin oligodendrocyte glycoprotein (MOG)-antibody-associated disease is expanding. Objective: To describe an unusual case of MOG-antibody-associated hypertrophic pachymeningitis (HP). Methods: Case study. Results: A 57 -year -old female presented with a generalised seizure on a background of 3 months history of progressive cognitive decline and behavioural changes. Brain Magnetic Resonance Imaging (MRI) revealed widespread pachymeningeal enhancement and hyperintense signal in both hippocampi. Cerebrospinal Fluid (CSF) examination was normal. The patient was found positive for MOG-antibody. She clinically improved with steroids and the MRI abnormalities completely resolved. Conclusions: Clinicians might consider testing for MOG-antibody in cases with HP.
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页数：3
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