The level of native and oxidized lipoprotein(a) in children with nephrotic syndrome

被引：13

作者：

Li, Han-qing ^{[1
]}

Wu, Jia ^{[1
]}

Niu, Dong-Mei ^{[1
]}

Shi, Yong-Hui ^{[1
]}

Zhang, Chun-ni ^{[1
]}

Wang, Jun-jun ^{[1
]}

机构：

[1] Nanjing Univ, Jinling Hosp, Dept Biochem, Sch Clin Med, Nanjing 210002, Jiangsu, Peoples R China

来源：

CLINICAL BIOCHEMISTRY | 2012年 / 45卷 / 1-2期

基金：

中国国家自然科学基金;

关键词：

Lipoproteins; Lipoprotein(a); Oxidative stress; Nephrotic syndrome; Atherosclerosis; LOW-DENSITY-LIPOPROTEIN; APOLIPOPROTEIN(A) PHENOTYPES; PLASMA LIPOPROTEIN(A); LIPID-PEROXIDATION; ANTIOXIDANT STATUS; OXIDATIVE STRESS; IMMUNE-COMPLEXES; METABOLISM; DYSLIPIDEMIA; HEMODIALYSIS;

D O I：

10.1016/j.clinbiochem.2011.11.002

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objective: To investigate lipoprorein(a) [Lp(a)], oxidized Lp(a) [ox-Lp(a)] and Lp(a) immune complex [Lp(a)-IC] levels in children with nephrotic syndrome (NS). Design and methods: Plasma Lp(a), ox-Lp(a) and Lp(a)-IC levels were determined in 106 NS children in acute-period, 42 in remission and 155 controls. Results: Lp(a) and ox-Lp(a) levels were significantly higher in acute-period and remission NS than in control. Ox-Lp(a) levels in acute-period NS were higher than in remission. Lp(a)-IC levels in acute-period NS were higher than in control. Lp(a), ox-Lp(a) and Lp(a)-IC were found negatively related with albumin in NS. Lp (a), ox-Lp(a) and Lp(a)-IC levels decreased after use of steroid therapy. Multiple linear regression analysis found relative change of albumin, creatinine, urea, triglyceride and high density lipoprotein cholesterol accounted for 78.9% of variation in ox-Lp(a). Conclusions: Lp(a), ox-Lp(a) and Lp(a)-IC levels were increased in NS children, which may play an important role in the processes of atherosclerosis. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：101 / 105

页数：5

共 40 条

[1] Interventions for preventing and treating kidney disease in Henoch-Schonlein Purpura (HSP) (Review) [J].

Chartapisak, Wattana ;

Opastirakul, Sauwalak ;

Hodson, Elisabeth M. ;

Willis, Narelle S. ;

Craig, Jonathan C. .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2009, (03)

[2]

Craig WY, 1998, CLIN CHEM, V44, P2301

[3] Effect of corticosteroids and eicosapentaenoic acid/docosahexaenoic acid on pro-oxidant and anti-oxidant status and metabolism of essential fatty acids in patients with glomerular disorders [J].

Das, UN ;

Mohan, IK ;

Raju, TR .

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2001, 65 (04) :197-203

[4]

De Sain-Van der Velden MGM, 1998, J AM SOC NEPHROL, V9, P1474

[5]

Dieplinger H, 1999, WIEN KLIN WOCHENSCHR, V111, P5

[6] Paraoxonase, total antioxidant response, and peroxide levels in children with steroid-sensitive nephrotic syndrome [J].

Ece, A ;

Atamer, Y ;

Gürkan, F ;

Davutoglu, M ;

Koçyigit, Y ;

Tutanç, M .

PEDIATRIC NEPHROLOGY, 2005, 20 (09) :1279-1284

[7] Anti-oxidant status in relation to lipoproteins, leptin and pro-inflammatory cytokines in children with steroid-sensitive nephrotic syndrome [J].

Ece, A ;

Atamer, Y ;

Gürkan, F ;

Bilici, M ;

Koçyigit, Y .

NEPHROLOGY, 2004, 9 (06) :366-373

[8] Oxidative modification of low-density lipoprotein in relation to dyslipidemia and oxidant status in children with steroid sensitive nephrotic syndrome [J].

El-Melegy, Nagla T. ;

Mohamed, Nagwa A. ;

Sayed, Mohmed M. .

PEDIATRIC RESEARCH, 2008, 63 (04) :404-409

[9]

FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499

[10] In vivo turnover study demonstrates diminished clearance of lipoprotein(a) in hemodialysis patients [J].

Frischmann, M. E. ;

Kronenberg, F. ;

Trenkwalder, E. ;

Schaefer, J. R. ;

Schweer, H. ;

Dieplinger, B. ;

Koenig, P. ;

Ikewaki, K. ;

Dieplinger, H. .

KIDNEY INTERNATIONAL, 2007, 71 (10) :1036-1043

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