Ibuprofen Potentiates the In Vivo Antifungal Activity of Fluconazole against Candida albicans Murine Infection

被引：29

作者：

Costa-de-Oliveira, Sofia ^{[1
,2
]}

Miranda, Isabel M. ^{[1
,2
]}

Silva-Dias, Ana ^{[1
,2
]}

Silva, Ana P. ^{[1
,2
]}

Rodrigues, Acacio G. ^{[1
,2
,3
]}

Pina-Vaz, Cidalia ^{[1
,2
,3
,4
]}

机构：

[1] Univ Porto, Dept Microbiol, Fac Med, P-4100 Oporto, Portugal

[2] Univ Porto, Fac Med, CINTESIS Ctr Hlth Technol & Serv Res, P-4100 Oporto, Portugal

[3] Hosp Sao Joao, Dept Plast & Reconstruct Surg, Burn Unit, Oporto, Portugal

[4] Hosp Sao Joao, Dept Microbiol, Oporto, Portugal

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2015年 / 59卷 / 07期

关键词：

RESISTANCE MECHANISMS; DRUG-RESISTANCE; AGENTS; AZOLES; EXPRESSION; FUNGEMIA; TARGET; MODEL; VITRO;

D O I：

10.1128/AAC.05056-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Candida albicans is the most prevalent cause of fungemia worldwide. Its ability to develop resistance in patients receiving azole antifungal therapy is well documented. In a murine model of systemic infection, we show that ibuprofen potentiates fluconazole antifungal activity against a fluconazole-resistant strain, drastically reducing the fungal burden and morbidity. The therapeutic combination of fluconazole with ibuprofen may constitute a new approach for the management of antifungal therapeutics to reverse the resistance conferred by efflux pump overexpression.

引用

页码：4289 / 4292

页数：4

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